gene 851 words KG: VDAC2 2026-03-24
kind:genesection:genesstate:published
Contents

VDAC2 — Voltage-Dependent Anion Channel 2

🧬 Gene Info
Gene SymbolVDAC2
Full NameVoltage-Dependent Anion Channel 2
Chromosome10q22.2
Function### Mitochondrial Metabolite Transport
Primary ExpressionUbiquitous, high in brain, heart, skeletal muscle
Molecular Weight31.6 kDa
Amino Acids294 aa
PathwaysAutophagy, autophagy pathway, epigenetic regulation, mitophagy, oxidative stress response
UniProt IDP45880
NCBI Gene ID7417
Ensembl IDENSG00000165637
OMIM193245
GeneCardsVDAC2
Human Protein AtlasVDAC2
Associated DiseasesCancer, Cardiovascular, Inflammation, Ischemia, Ms, Neurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsBAX, TFEB, PRKN, GAIN, DMT1, CYBB
KG Connections215 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (16)

Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49

Related Analyses (7)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (10)

Packard Center for ALS Research
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
BAX Gene
gene · KG edge: inhibits
ATF4 Gene
gene · KG edge: activates
ar
gene · KG edge: activates

Knowledge Graph (12 edges)

VDAC2 associated_with ESR2
VDAC2 associated_with AMBRA1
VDAC2 inhibits IFN-γ
VDAC2 inhibits IFN-gamma-mediated tumor destruction
VDAC2 associated_with BECN1
VDAC2 associated_with GLA
VDAC2 associated_with ULK1
VDAC2 associated_with ESR1
VDAC2 associated_with FYCO1
VDAC2 associated_with PSEN2