protein 919 words KG: DMT1 2026-03-19
kind:proteinsection:proteinsstate:published
Contents

DMT1 (Divalent Metal Transporter 1)

🔬 Protein Info
Gene SymbolDMT1
AliasesSLC11A2, Divalent Metal Transporter 1
Chromosome12q14.2
Protein TypeTransporter
FunctionDMT1 is the primary transporter for non-heme iron uptake
Subcellular LocalizationPlasma membrane, Endosomes, Lysosomes
Molecular Weight54 kDa
Amino Acids495 aa
PathwaysFerroptosis, Inflammasome, Nf-Κb, Oxidative Stress, Synaptic Plasticity
UniProt ID[P49281](https://www.uniprot.org/uniprot/P49281)
GeneCardsDMT1
Human Protein AtlasDMT1
Associated DiseasesParkinson's disease
Known Drugs/CompoundsDietary Iron, Dietary iron
InteractionsGPX4, KEAP1, NRF2, JNK, P62, CYBB
KG Connections142 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

Senescence-Induced Lipid Peroxidation Spreading
Score: 0.53
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.47
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (4)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Metal Ion Homeostasis Dysregulation in Alzheimer's Disease
validation · proposed · Score: 0.40

See Also (8)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: inhibits
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
CYBB — Cytochrome b-245, Beta Polypeptide
gene · KG edge: activates
BECN1 Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

DMT1 activates GPX4
DMT1 associated_with TFR1
DMT1 activates KEAP1
DMT1 activates NRF2
DMT1 transports FERROPORTIN
DMT1 targets Dietary Iron
DMT1 inhibits JNK
DMT1 expressed_in FTH1
DMT1 expressed_in SLC7A11
DMT1 expressed_in TFR1