DMT1

Understanding Entity Pages

This page aggregates everything SciDEX knows about DMT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Comprehensive information on DMT1 (SLC11A2), a divalent metal transporter involved in iron homeostasis and neurodegenerative diseases

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graph TD
    DMT1["<b>DMT1</b>"]
    Cancer{"Cancer"}
    DMT1 -->|"regulates"| Cancer
    Ms{"Ms"}
    DMT1 -->|"regulates"| Ms
    DMT1 -->|"activates"| Ms
    Als{"Als"}
    DMT1 -->|"contributes to"| Als
    DMT1 -->|"activates"| Cancer
    GPX4["GPX4"]
    DMT1 -->|"activates"| GPX4
    Ferroptosis(["Ferroptosis"])
    DMT1 -->|"activates"| Ferroptosis
    TFR1["TFR1"]
    DMT1 -->|"associated with"| TFR1
    FERROPTOSIS["FERROPTOSIS"]
    DMT1 -->|"contributes to"| FERROPTOSIS
    KEAP1["KEAP1"]
    DMT1 -->|"activates"| KEAP1
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    DMT1 -->|"activates"| OXIDATIVE_STRESS
    HO_1["HO-1"]
    DMT1 -->|"activates"| HO_1
    TFR1 -->|"associated with"| DMT1
    TFR1 -->|"activates"| DMT1
    NCOA4["NCOA4"]
    NCOA4 -->|"contributes to"| DMT1
    P62["P62"]
    P62 -->|"activates"| DMT1
    FERROPORTIN["FERROPORTIN"]
    FERROPORTIN -->|"transports"| DMT1
    TFR1 -->|"transports"| DMT1
    AND["AND"]
    AND -->|"transports"| DMT1
    style DMT1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0