protein 951 words KG: HIF1A 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

HIF-1α Protein

🔬 Protein Info
Gene SymbolHIF
Full Name1α Protein
AliasesHIF1A
GeneCardsHIF
Human Protein AtlasHIF
CategoryRepresentative Genes
GlycolysisGLUT1, HK2, LDHA, PDK1
AngiogenesisVEGF, ANGPT2, PDGF
ErythropoiesisEPO (erythropoietin)
Iron metabolismTransferrin, TFRC, DMT1
pH regulationCA9, CA12 (carbonic anhydrases)
Cell survivalBNIP3, NIX (mitophagy)
InflammationiNOS, COX-2
InteractorRelationship
HIF-1β/ARNTDimerization partner
Associated DiseasesAD, ALI, ALS, AMI, ARM
Known Drugs/Compoundsrapamycin, quercetin
InteractionsGAIN, IDH2, TKT, CANCER, TIGAR, AMPK
KG Connections1362 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Perinatal Hypoxia-Primed Microglia Targeting
Score: 0.38
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.51
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.48
Osmotic Gradient Restoration via Selective AQP1 Enhancement
Score: 0.43
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.39

Related Analyses (15)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

See Also (15)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
AKT1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

HIF1A regulates SLC7A11
HIF1A interacts_with MAP1LC3B
HIF1A interacts_with GBA
HIF1A interacts_with FUNDC1
HIF1A interacts_with AMBRA1
HIF1A interacts_with PINK1
HIF1A interacts_with BCL2L13
HIF1A interacts_with NLRP3
HIF1A interacts_with ABCD3
HIF1A interacts_with FIP200