| Gene Symbol | MAP3K12 |
| Full Name | Mitogen-Activated Protein Kinase Kinase Kinase 12 |
| Protein Type | Kinase |
| Function | MAP3K12 (Mitogen-Activated Protein Kinase Kinase Kinase 12), also known as DLK (Dual-Leucine Zipper Kinase), is a serine/threonine protein kinase that functions as a key regulator of stress-activated |
| Primary Expression | neurons throughout the CNS - Regional Distribution: High expression in hippocampus, cortex |
| Pathways | MAPK pathway |
| GeneCards | MAP3K12 |
| Human Protein Atlas | MAP3K12 |
| Stress response | Activation of JNK/p38 pathways in response to oxidative stress, cytokines, and injury |
| Axonal injury signaling | Critical for axonal degeneration after injury (SARM1-independent pathway) |
| Synaptic plasticity | Regulates dendritic spine morphology and synaptic function |
| Axon guidance | Regulation of axonal pruning during development |
| Neuropathic pain | Sensitization of nociceptive neurons |
| Neurodegeneration | Activation of pro-apoptotic pathways |
| Brain | Widely expressed in neurons throughout the CNS |
| Associated Diseases | neurodegeneration |
| Interactions | DRP1 |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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