gene 524 words KG: DRP1 2026-03-24
kind:genesection:genesstate:published
Contents

DRP1 Gene - Dynamin 1-Like Protein

🧬 Gene Info
Gene SymbolDRP1
Protein TypeEnzyme
FunctionThe DRP1 gene encodes a 736-amino acid GTPase
PathwaysApoptosis, Autophagy, Cell Cycle, Complement, Dna Methylation
Ensembl IDENSG00000141971
GeneCardsDRP1
Human Protein AtlasDRP1
Mitochondrial fissionMediates scission of mitochondrial outer membrane
GTP hydrolysisSelf-assembles into rings that hydrolyze GTP to drive membrane constriction
Associated DiseasesAD, ALI, ALS, Aging, Alzheimer
Known Drugs/Compoundspropionic acid, ginsenoside Re, Zuo Gui Wan, Rg1, Mdivi-1, Palmitic Acid
InteractionsCHOP, BECN1, PTEN, DDIT3, NBR1, EMD
KG Connections1718 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Adenosine-Astrocyte Metabolic Reset
Score: 0.56
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61

Related Analyses (18)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

See Also (8)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
AKT1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

DRP1 activates EIF2AK3
DRP1 activates EIF2S1
DRP1 activates EMD
DRP1 activates EPAS1
DRP1 activates ERN1
DRP1 activates FAM134B
DRP1 activates FIP200
DRP1 activates FMR1
DRP1 activates FUNDC1
DRP1 activates G3BP1