mechanism 2,025 words KG: ent-gene-83d99ff1 2026-03-22
kind:mechanismsection:mechanismsstate:published
Contents

FUS Protein in Amyotrophic Lateral Sclerosis

🔬 Protein Info
Gene Symbolent-gene-83d99ff1
N-terminal low-complexity domain (LCD)Prion-like domain involved in phase separation
RNA recognition motif (RRM)Binds RNA sequences
Zinc finger domain (ZF)RNA binding
Nuclear localization signal (NLS)Nuclear import
C-terminal proline-rich regionProtein interactions
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

TREM2-mediated microglial tau clearance enhancement
Score: 0.49
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Vagal Afferent Microbial Signal Modulation
Score: 0.52
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59

Related Analyses (30)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
Microglial subtypes in neurodegeneration — friend vs foe
neuroscience · failed
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · completed

Related Experiments (6)

s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40
ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40
iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90

Knowledge Graph (2 edges)

ent-gene-83d99ff1 data_in benchmark_ot_ad_answer_key:FUS
benchmark_ot_ad_answer_key:FUS data_in ent-gene-83d99ff1