| Gene Symbol | ent-gene-2488b5f0 |
| Destabilized dimer interface | Mutations weaken SOD1 dimer stability |
| Reduced metal binding | Loss of zinc/copper cofactors increases aggregation |
| Increased hydrophobic exposure | Promotes oligomerization and aggregation |
| Post-translational modifications | Oxidation, nitration accelerate aggregation |
| Direct binding | Mutant SOD1 binds to mitochondria |
| Complex I inhibition | Reduced ATP production |
| Calcium handling | Impaired mitochondrial calcium buffering |
| Drp1 dysregulation | Abnormal mitochondrial fission |
| Apoptosis | Cytochrome c release, caspase activation |
| Aberrant peroxidase activity | Mutant SOD1 can use substrates improperly |
| Nitric oxide interaction | Forms peroxynitrite |
| Lipid peroxidation | Membrane damage |
| DNA damage | 8-OHdG accumulation |
| Reduced glutamate transport | EAAT2 downregulation |
| AMPA receptor dysregulation | Calcium-permeable AMPA receptors |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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