| Gene Symbol | ent-gene-28e2cb01 |
| Transmembrane helix | Single pass through the membrane |
| Cytoplasmic tail | Short tail lacking intrinsic signaling capacity |
| Cholecalciferol (D3) | Synthesized in skin upon UVB exposure, also obtained from diet |
| Ergocalciferol (D2) | Obtained from plant sources |
| 25-hydroxyvitamin D [25(OH)D] | Major circulating form, measured in clinical assays |
| 1,25-dihydroxyvitamin D [1,25(OH)2D] | Active hormone form |
| Vitamin D receptor (VDR) | Nuclear receptor in neurons, astrocytes, and microglia |
| CYP27B1 | 1-alpha hydroxylase for local activation |
| CYP24A1 | Catabolic enzyme regulating vitamin D levels |
| Binding affinity | Kd approximately 100 nM as measured by surface plasmon resonance |
| Binding site | Extracellular immunoglobulin domain of TREM2 |
| Species conservation | Functional binding observed in human, rat, and mouse systems |
| Specificity | Cholecalciferol does not bind to related receptors (TREM1, TREML2) |
| KG Connections | 94 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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