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therapeutic 1,090 words KG: ent-gene-28e2cb01 2026-03-23
kind:therapeuticsection:therapeuticsstate:published
Contents

TREM2 Agonist Therapies for Alzheimer's Disease

🔬 Protein Info
Gene Symbolent-gene-28e2cb01
VariantRisk Increase
R47H~3-4x
R62H~2x
H157Y~3x
T96K~2x
Y38C~5x
TrialPhase
INVOKE-2Phase II
LAKEPhase II
INVOKE-2 extensionPhase II
BiomarkerExpected Change
sTREM2Increase
[NfL](/proteins/nfl-protein)Decrease
p-[tau](/proteins/tau)Decrease
[Aβ42](/proteins/amyloid-beta)Increase (in CSF)
KG Connections5 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.59Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.83ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.83Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82TREM2-mediated microglial tau clearance enhancement
Score: 0.80

Related Analyses (30)

Synaptic pruning by microglia in early AD
neurodegeneration · completedImmune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · completedNeuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archivedNeuroinflammation and microglial priming in early AD
neurodegeneration · completedDoes SYK activation provide neuroprotection or exacerbate ne
neurodegeneration · archived

Related Experiments (30)

Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.40TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.40TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.40TREM2 KO amyloid pathology study
validation · completed · Score: 0.75TREM2 KO amyloid pathology study
validation · completed · Score: 0.75

Key Papers (3)

TREM2 variants in Alzheimer's disease.
The New England journal of med 2013A Unique Microglia Type Associated with Restricting Development of Alz
Cell 2017TREM2 lipid sensing sustains the microglial response in an Alzheimer's
Cell 2015

See Also (15)

Vascular Dementia Mechanisms — Overlap with Alzheimer's
mechanism · Pages share 19 hypothesesUbiquitin-Proteasome System Dysfunction in Alzheimer's
mechanism · Pages share 18 hypothesesTau Kinase Signaling Cascade in Alzheimer's Disease
mechanism · Pages share 18 hypothesesTau Kinase-Phosphatase Balance in Alzheimer's Disease
mechanism · Pages share 18 hypothesesSynaptic Loss in Alzheimer's Disease Pathway
mechanism · Pages share 19 hypotheses

Knowledge Graph (5 edges)

ent-gene-28e2cb01 expressed_in microglia
ent-gene-28e2cb01 data_in ad_genetic_risk_loci:TREM2
ent-gene-28e2cb01 data_in benchmark_ot_ad_answer_key:TREM2
ad_genetic_risk_loci:TREM2 data_in ent-gene-28e2cb01
benchmark_ot_ad_answer_key:TREM2 data_in ent-gene-28e2cb01

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