mechanism 1,179 words KG: ent-gene-6a42454e 2026-04-01
kind:section:mechanismsevidence:strongmechanismsection:mechanismsstate:publishedtopic:alzheimerstopic:causal-chainstopic:complementtopic:synaptic-pruning
Contents

CR1→Complement Activation→Synaptic Pruning→AD Causal Chain

🔬 Protein Info
Gene Symbolent-gene-6a42454e
SummaryComplete causal chain tracing CR1 genetic variants through complement dysregulation, excessive synaptic pruning, to Alzheimer's disease pathogenesis
KG Connections4 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Microbial Inflammasome Priming Prevention
Score: 0.58

Related Analyses (30)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

Related Experiments (2)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40

Knowledge Graph (4 edges)

ent-gene-6a42454e data_in ad_genetic_risk_loci:CR1
ent-gene-6a42454e data_in benchmark_ot_ad_answer_key:CR1
ad_genetic_risk_loci:CR1 data_in ent-gene-6a42454e
benchmark_ot_ad_answer_key:CR1 data_in ent-gene-6a42454e