| Gene Symbol | DJ |
| Full Name | 1/PARK7 Neuroprotection Pathway in Parkinson's Disease |
| Function | Dj 1 Protein (Park7) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| GeneCards | DJ |
| Human Protein Atlas | DJ |
| Loss-of-function mutations | Cause autosomal recessive PD |
| Protein stability mutations | Affect DJ-1 folding |
| Splice site mutations | Alter proper RNA processing |
| Deletion mutations | Found in some families |
| Direct antioxidant activity | DJ-1 can directly scavenge reactive oxygen species (ROS) through its cysteine residues (particularly C106), acting as a redox sensor and antioxidant |
| p53 modulation | DJ-1 can inhibit p53-mediated apoptosis under oxidative stress conditions |
| FoxO transcription factor protection | DJ-1 prevents FoxO transcription factor degradation, maintaining expression of stress-resistance genes |
| Mitochondrial localization | DJ-1 localizes to mitochondria under oxidative stress conditions, where it directly protects complex I activity and maintains mitochondrial membrane potential |
| Mitophagy regulation | DJ-1 interacts with the PINK1/PARKIN mitophagy pathway, stabilizing PINK1 on damaged mitochondria and promoting selective removal of dysfunctional mitochondria |
| Mitochondrial dynamics | DJ-1 helps maintain proper mitochondrial dynamics by regulating fission and fusion proteins |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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