Contents

FUS Proteinopathy

🔬 Protein Info

Gene Symbol	ent-gene-83d99ff1
Function	Planning and decision-making deficits
N-terminal prion-like domain	Low-complexity regions that facilitate liquid-liquid phase separation
RNA recognition motifs (RRMs)	Bind specific RNA sequences
Zinc finger domain	Mediates nucleic acid binding
C-terminal prion-like domain	Enables protein-protein interactions
Rapid progression	Faster disease than sporadic ALS
Younger age of onset	Often presents before age 40
Bulbar onset	Higher frequency of bulbar involvement
Cognitive involvement	Some patients develop FTD features
Upper motor neuron predominance	Prominent corticospinal tract involvement
KG Connections	2 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Knowledge Graph