mechanism 2,674 words KG: ent-gene-694200ea 2026-03-24
kind:mechanismsection:mechanismsstate:published
Contents

GBA Glucocerebrosidase Endolysosomal Pathway in Parkinson's Disease

🔬 Protein Info
Gene Symbolent-gene-694200ea
FunctionHydrolyzes glucosylceramide to glucose + ceramide
GeneGBA (Glucocerebrosidase)
ProteinGCase - lysosomal hydrolase (536 amino acids)
LocationLysosome lumen
PD RiskHeterozygous mutations increase risk 5-20x
InheritanceAutosomal recessive (homozygous = Gaucher disease)
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (22)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Circadian-Synchronized Proteostasis Enhancement
Score: 0.58
Smartphone-Detected Motor Variability Correction
Score: 0.56
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45
Transcriptional Autophagy-Lysosome Coupling
Score: 0.68

Related Analyses (30)

GBA-Synuclein Loop: Therapeutic Strategies for Parkinson's D
neurodegeneration · completed
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (30)

Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Genetic Risk Modifiers in DLB Phenotype
clinical · proposed · Score: 0.40
DLB Treatment Response Biomarkers — Predicting Cholinesteras
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-694200ea data_in benchmark_ot_ad_answer_key:GBA
benchmark_ot_ad_answer_key:GBA data_in ent-gene-694200ea