| Gene Symbol | ent-gene-694200ea |
| Chromosome | 1q21 |
| Lysosomal function | Maintains proper lysosomal degradation capacity |
| Autophagy regulation | Supports macroautophagy and chaperone-mediated autophagy |
| Calcium homeostasis | Influences lysosomal calcium storage and signaling |
| Mitochondrial function | Affects mitochondrial quality control mechanisms |
| Protein homeostasis | Helps maintain cellular proteostasis through lysosomal pathways |
| Earlier onset | Average onset 5-10 years earlier than idiopathic PD |
| More rapid progression | Faster cognitive decline and motor progression |
| Higher prevalence of non-motor symptoms | More frequent cognitive impairment, psychosis, and autonomic dysfunction |
| Increased Lewy body pathology | More widespread alpha-synuclein pathology |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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