Contents

LRRK2 Transgenic Mouse Model for Parkinson's Disease

🔬 Protein Info

Gene Symbol	ent-gene-9f063e98
Tyrosine hydroxylase (TH) promoter	Drives expression specifically in dopaminergic neurons, targeting the substantia nigra pars compacta and ventral tegmental area[@cannon2023]
CaMKIIα promoter	Targets excitatory neurons in the cortex and hippocampus, useful for studying non-dopaminergic effects[@melrose2022]
CMV promoter	Pan-neuronal expression throughout the brain[@liu2023]
BAC-derived models	Maintain endogenous LRRK2 expression patterns with natural 3' and 5' regulatory elements[@baczmanski2022]
KG Connections	22 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING