| Gene Symbol | ent-gene-7b80a607 |
| Function | - ULK1 inhibition: Persistent mTORC1 activity blocks ULK1 complex activation |
| ULK1 inhibition | Persistent mTORC1 activity blocks ULK1 complex activation |
| TFEB mislocalization | mTOR phosphorylates TFEB, preventing nuclear translocation |
| Lysosomal dysfunction | Reduced lysosomal biogenesis impairs tau clearance |
| Regional specificity | mTOR dysregulation is most severe in globus pallidus and substantia nigra |
| Asymmetric presentation | mTOR activity often higher in more affected hemisphere |
| Neuronal loss correlation | mTOR hyperactivity correlates with neuronal loss in affected cortices |
| Astrocytic involvement | Reactive astrocytes show mTOR activation |
| TFEB nuclear exclusion | Similar to PSP, TFEB is retained in cytoplasm |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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