| Gene Symbol | PKC |
| Full Name | Protein Kinase C Alpha |
| Chromosome | 17q24.2 |
| Protein Family | PKC (Protein Kinase C) family |
| Subcellular Localization | s, and functions in neurons, making them attractive yet challenging therapeutic targets[@newton2024] |
| Amino Acids | 672 aa |
| Exons | 17 |
| Pathways | Akt, Apoptosis, Autophagy, Complement, Differentiation |
| UniProt ID | [P17252](https://www.uniprot.org/uniprot/P17252) |
| Ensembl ID | ENSG00000154229 |
| OMIM | 176960 |
| GeneCards | PKC |
| Human Protein Atlas | PKC |
| PRKCA (PKC-α) | Widely expressed in the brain, involved in synaptic plasticity and neurotransmitter release |
| PRKCB (PKC-β) | Two splice variants (βI, βII), enriched in neurons and microglia |
| Associated Diseases | ALS, Alzheimer, Ataxia, Diabetes, Ms |
| Known Drugs/Compounds | metformin |
| Interactions | TNF, FYN, KEAP1, CUL3, BACH1, ANG |
| KG Connections | 541 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |