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Mechanism: Synaptic Dysfunction in Progressive Supranuclear Palsy
mechanism
2,238 words
KG: synaptic_dysfunction
2026-03-22
kind:mechanism
section:mechanisms
state:published
Contents
Synaptic Dysfunction in Progressive Supranuclear Palsy
⚙
Mechanism Info
Name
Synaptic Dysfunction in Progressive Supranuclear Palsy
Summary
Page for Synaptic Dysfunction in Progressive Supranuclear Palsy
Key Genes/Proteins
protein_oligomers
Related Diseases
neurodegeneration
Linked Hypotheses
1 hypotheses
Knowledge Graph
Related Hypotheses (20)
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SASP-Mediated Cholinergic Synapse Disruption
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Vocal Cord Neuroplasticity Stimulation
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Epigenetic Memory Reprogramming for Alzheimer's Disease
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Microbial Metabolite-Mediated α-Synuclein Disaggregation
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Excitatory Neuron Vulnerability via SLC17A7 Downregulation
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Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.43
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.34
APOE-Dependent Autophagy Restoration
Score: 0.61
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.42
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41
Synaptic Vesicle Tau Capture Inhibition
Score: 0.34
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.51
Age-Dependent Complement C4b Upregulation Drives Synaptic Vu
Score: 0.47
APOE-Mediated Synaptic Lipid Raft Stabilization
Score: 0.43
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.40
Brain Insulin Resistance with Glucose Transporter Dysfunctio
Score: 0.40
Complement-Mediated Synaptic Pruning Dysregulation
Score: 0.40
Show 15 more
Related Analyses (30)
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Do tau strains or regional cellular environments primarily d
neurodegeneration · failed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · completed
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What are the mechanisms by which gut microbiome dysbiosis in
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Show 25 more
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clinical · proposed · Score: 0.40
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clinical · proposed · Score: 0.40
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Show 18 more
See Also (3)
C3 — Complement Component 3
gene · KG edge: causes
Neurodegeneration
disease · KG edge: contributes_to
CA2 Pyramidal Neurons
cell · KG edge: causes
Knowledge Graph (2 edges)
synaptic_dysfunction
contributes_to
neurodegeneration
protein_oligomers
causes
synaptic_dysfunction