mechanism 2,155 words KG: ent-gene-28e2cb01 2026-03-25
kind:mechanismsection:mechanismsstate:publishedevidence:strong
Contents

TREM2+ Border-Associated Macrophages

🔬 Protein Info
Gene Symbolent-gene-28e2cb01
Dural macrophagesReside in the dural sinus areas, interact with venous blood
Arachnoid trabecular macrophagesFound within the arachnoid trabeculae
Pial macrophagesLie on the brain surface beneath the pia mater
Vascular smooth muscle cell-associatedAlong penetrating arterioles
Capillary-associatedNear the neurovascular unit
Venular macrophagesAlong post-capillary venules
Epithelial-associated macrophagesNear the choroid plexus epithelium
Meningeal macrophagesHigh TREM2 expression
Perivascular macrophagesModerate to high expression
Choroid plexus macrophagesVariable expression
Comparison to microgliaSimilar expression levels
KG Connections5 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegen
Score: 0.64
TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene
Score: 0.61
TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegener
Score: 0.61
TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming
Score: 0.59
TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging
Score: 0.59

Related Analyses (30)

Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · completed
Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived
Neuroinflammation and microglial priming in early AD
neurodegeneration · completed
TREM2 Therapeutic Strategy Post-INVOKE-2
neurodegeneration · archived
Mechanistic validation of SEA-AD differential expression hyp
neurodegeneration · failed

Related Experiments (30)

Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.40
TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.40
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.40
TREM2 KO amyloid pathology study
validation · completed · Score: 0.75
TREM2 KO amyloid pathology study
validation · completed · Score: 0.75

See Also (7)

TREM2 Gene-Mechanism-Therapy Chain — From Genetic Risk
mechanism · Pages share 3 hypotheses
TREM2 in Frontotemporal Dementia
mechanism · Pages share 3 hypotheses
TREM2 in Amyotrophic Lateral Sclerosis
mechanism · Pages share 3 hypotheses
TREM2 Gene
gene · Pages share 3 hypotheses
al002-trem2-agonist-alzheimers
clinical_trial · Pages share 3 hypotheses

Knowledge Graph (5 edges)

ent-gene-28e2cb01 expressed_in microglia
ent-gene-28e2cb01 data_in ad_genetic_risk_loci:TREM2
ent-gene-28e2cb01 data_in benchmark_ot_ad_answer_key:TREM2
ad_genetic_risk_loci:TREM2 data_in ent-gene-28e2cb01
benchmark_ot_ad_answer_key:TREM2 data_in ent-gene-28e2cb01