mechanism 3,181 words KG: ent-gene-28e2cb01 2026-03-22
kind:mechanismsection:mechanismsstate:publishedevidence:strong
Contents

TREM2 in Parkinson's Disease — Cross-Disease Therapeutic Opportunity

🔬 Protein Info
Gene Symbolent-gene-28e2cb01
SYK activationPhosphorylation of SYK kinase leads to PLCgamma2 activation and calcium signaling[@bose2021]
PI3K/Akt pathwayPromotes cell survival and metabolic fitness
MAPK pathwaysRegulates inflammatory gene expression
NF-kB signalingControls cytokine and chemokine production
KG Connections5 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegen
Score: 0.64
TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene
Score: 0.61
TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegener
Score: 0.61
TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming
Score: 0.59

Related Analyses (30)

Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · completed
Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived
Neuroinflammation and microglial priming in early AD
neurodegeneration · completed
TREM2 Therapeutic Strategy Post-INVOKE-2
neurodegeneration · archived
Mechanistic validation of SEA-AD differential expression hyp
neurodegeneration · failed

Related Experiments (30)

TREM2 KO amyloid pathology study
validation · completed · Score: 0.75
TREM2 KO amyloid pathology study
validation · completed · Score: 0.75
TREM2 KO amyloid pathology study
validation · in_progress · Score: 0.75
TREM2 KO amyloid pathology study
validation · completed · Score: 0.75
TREM2 KO amyloid pathology study
validation · completed · Score: 0.75

See Also (15)

TREM2 Gene-Mechanism-Therapy Chain — From Genetic Risk
mechanism · Pages share 4 hypotheses
Vascular Dementia Mechanisms — Overlap with Alzheimer's
mechanism · Pages share 3 hypotheses
TREM2 in Frontotemporal Dementia
mechanism · Pages share 3 hypotheses
TREM2 in Amyotrophic Lateral Sclerosis
mechanism · Pages share 3 hypotheses
Synaptic Loss in Alzheimer's Disease Pathway
mechanism · Pages share 3 hypotheses

Knowledge Graph (5 edges)

ent-gene-28e2cb01 expressed_in microglia
ent-gene-28e2cb01 data_in ad_genetic_risk_loci:TREM2
ent-gene-28e2cb01 data_in benchmark_ot_ad_answer_key:TREM2
ad_genetic_risk_loci:TREM2 data_in ent-gene-28e2cb01
benchmark_ot_ad_answer_key:TREM2 data_in ent-gene-28e2cb01