gene 675 words KG: ent-gene-f0e422a0 2026-03-29
kind:genesection:genestopic:alzheimerstopic:parkinsonsstate:publishedmitftranscription-factormicroglialysosomephagocytosis
Contents

MITF Gene

🧬 Gene Info
Gene SymbolMITF
Full NameMicrophthalmia-Associated Transcription Factor
Chromosome3p13
Protein FamilybHLH-Zip (MITF/TFEB/TFE3/TFEC)
FunctionLysosomal biogenesis, phagocytosis, melanogenesis
Primary ExpressionMelanocytes, microglia, retinal pigment epithelium
Amino Acids150 aa
PathwaysDna Repair, Mapk, Pi3K/Akt
UniProt IDO75030
NCBI Gene ID4283
Ensembl IDENSG00000186766
OMIM156845
GeneCardsMITF
Human Protein AtlasMITF
IsoformExpression
Associated DiseasesALS, Cancer, Melanoma, Ovarian Cancer, Pancreatic Cancer
InteractionsTFE3, STING, GABARAP, FLCN, CGAS, TFEB
SciDEX HypothesesMITF Acts as the Primary Transcriptional Effector
KG Connections264 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (24)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
APOE-TREM2 Interaction Modulation
Score: 0.48

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived

Knowledge Graph (2 edges)

ent-gene-f0e422a0 data_in benchmark_ot_ad_answer_key:MITF
benchmark_ot_ad_answer_key:MITF data_in ent-gene-f0e422a0