protein 735 words KG: ABHD12PROTEIN
Contents

ABHD12 Protein - Alpha/Beta Hydrolase Domain Containing 12

🔬 Protein Info
Gene SymbolABHD12
Full NameAlpha/Beta Hydrolase Domain Containing 12
Chromosome20p11.21
Protein TypeHydrolase
Functionencodes a brain-enriched serine hydrolase enzyme that plays critical roles in lipid metabolism, endocannabinoid signaling, and neuroimmune function.
Primary Expressionthe central nervous system, particularly in neurons, microglia, and oligodendrocytes, where it hydrolyzes various lipid substrates including monoacylg
Exons14
UniProt IDQ9NWU1
NCBI Gene ID553155
Ensembl IDENSG00000153048
OMIM613599
GeneCardsABHD12
Human Protein AtlasABHD12
Associated DiseasesFreezing Tolerance
InteractionsBRCA1
KG Connections8 knowledge graph edges
DatabasesGeneCardsHPASTRING

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UniProtWikipedia

Related Hypotheses (8)

Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62

Related Analyses (10)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (3)

Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · completed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Microglial Contributions to Huntington's Disease Pathogenesi
validation · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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