protein

BRCA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BRCA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

462Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

BRCA1 is a protein involved in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with Aging, Als, Anxiety. Connected to 316 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	BRCA1
Full Name	BRCA1 DNA Repair Associated
Chromosome	17q21
Function	BRCA1 is a key component of the DNA damage response machinery
Primary Expression	most tissues with high expression in: - Breast and ovarian epithelium - Testis - Brain (neurons and glia) - Proliferating cells
Pathways	Apoptosis, Autophagy, Cell Cycle, Dna Repair, Immune Response
UniProt ID	P38398
NCBI Gene ID	672
Ensembl ID	ENSG00000012048
OMIM	113705
GeneCards	BRCA1
Human Protein Atlas	BRCA1
Approach	Status
PARP inhibitors	Approved (cancer)
BRCA1 restoration	Research
Associated Diseases	ALS, Breast Cancer, Cancer, Carcinoma, Melanoma
Interactions	RB1CC1, MTOR, GPX4, RAD51, SLC7A11, HNRNPH1
KG Connections	462 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BRCA1 — AlphaFold P38398 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    BRCA1["BRCA1"]
    BRCA1 -.biomarker for.-> Cancer["Cancer"]
    BRCA1 -.biomarker for.-> Als["Als"]
    BRCA1 -.biomarker for.-> Ms["Ms"]
    BRCA1 -->|"inhibits"| Tumor["Tumor"]
    BRCA1 -->|"regulates"| Aging["Aging"]
    SOX2["SOX2"] -.biomarker for.-> BRCA1
    GAIN["GAIN"] -.biomarker for.-> BRCA1
    BCL_2["BCL-2"] -.biomarker for.-> BRCA1
    OVERVIEW["OVERVIEW"] -.biomarker for.-> BRCA1
    AGING["AGING"] -->|"regulates"| BRCA1
    FOS["FOS"] -->|"target for"| BRCA1
    HIPPO["HIPPO"] -->|"expressed in"| BRCA1
    SP1["SP1"] -->|"target for"| BRCA1
    MIR_9_5P["MIR-9-5P"] -->|"expressed in"| BRCA1
    SIRT1["SIRT1"] -->|"target for"| BRCA1

Outgoing (305)

Target	Relation	Type	Str
Cancer	associated_with	disease	1.00
CANCER	associated_with	gene	1.00
GENES	associated_with	gene	1.00
Als	expressed_in	disease	0.95
BRCA2	associated_with	gene	0.90
Cancer	therapeutic_target	disease	0.85
Cancer	activates	disease	0.85
Tumor	activates	disease	0.85
Als	regulates	disease	0.85
Cancer	regulates	disease	0.85
Cancer	inhibits	disease	0.85
Als	therapeutic_target	disease	0.85
Tumor	therapeutic_target	disease	0.85
Aging	therapeutic_target	disease	0.85
Als	biomarker_for	disease	0.75
Als	associated_with	disease	0.75
Tumor	inhibits	disease	0.75
Als	activates	disease	0.75
Carcinoma	activates	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Breast Cancer	associated_with	disease	0.75
P62	activates	gene	0.70
PARP1	inhibits	gene	0.70
Ferroptosis	activates	pathway	0.70
Autophagy	activates	pathway	0.70
AUTOPHAGY	regulates	gene	0.70
Autophagy	regulates	pathway	0.70
CANCER	therapeutic_target	gene	0.70
GENES	expressed_in	gene	0.70
CANCER	activates	gene	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
Cancer	biomarker_for	disease	0.65
Tumor	associated_with	disease	0.65
Ms	biomarker_for	disease	0.65
Parkinson	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Aging	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Ms	activates	disease	0.65
Cardiovascular	regulates	disease	0.65
Ms	inhibits	disease	0.65
Neurodegeneration	regulates	disease	0.65
Longevity	regulates	disease	0.65
Ms	regulates	disease	0.65
Inflammation	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Ataxia	regulates	disease	0.65
Als	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Breast Cancer	therapeutic_target	disease	0.65

Incoming (157)

Source	Relation	Type	Str
PTEN	associated_with	gene	0.90
CDKN2A	associated_with	gene	0.70
TP53	associated_with	gene	0.70
ABHD12	interacts_with	protein	0.70
PARP1	inhibits	gene	0.70
BAP1	interacts_with	gene	0.70
CANCER	regulates	gene	0.70
CANCER	inhibits	gene	0.70
AUTOPHAGY	activates	gene	0.70
SOX2	biomarker_for	gene	0.60
ATM	associated_with	gene	0.60
GAIN	biomarker_for	gene	0.60
OVERVIEW	biomarker_for	gene	0.60
GABARAP	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
RB1	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
TBK1	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
LC3	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
FOS	therapeutic_target	gene	0.60
SP1	therapeutic_target	gene	0.60
SIRT1	therapeutic_target	gene	0.60
NCOA4	activates	gene	0.60
NPM1	regulates	gene	0.60
TP53	regulates	gene	0.60
CASP3	regulates	gene	0.60
MTOR	inhibits	gene	0.60
BAP1	inhibits	gene	0.60
SIRT6	regulates	gene	0.60
PARP1	regulates	gene	0.60
HNRNPA1	activates	gene	0.60
MYC	regulates	gene	0.60
DDX5	activates	gene	0.60
PIN1	regulates	gene	0.60
TRIM32	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
CD8	activates	gene	0.60
NBR1	interacts_with	gene	0.60
MAVS	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

BRCA1

Understanding Entity Pages

Summary

Wiki Pages (21)

BRCA1 Gene

Autophagy Mechanisms

DNA Damage Response Impairment Pathway

dna-damage-repair

Mitophagy Pathway in Neurodegeneration

HDAC6 Protein

HDAC6 Protein

DNA Damage Response in Alzheimer's Disease

UBE2V1 Gene (UEV-1)

ataxia-telangiectasia

RAD21 — Cohesin Complex Component in Neurodegeneration

Protein SUMOylation Pathway in Neurodegeneration

DOT1L Gene

E2F7 Gene

NBS1 (NBN)

Huntington's Disease Somatic CAG Expansion and DNA Repair

UBE2I Protein

fance

EBF3 — Early B-cell Factor 3