| Gene Symbol | ALOX15 |
| Full Name | ALOX15 - Arachidonate 15-Lipoxygenase |
| Aliases | Arachidonate 15-Lipoxygenase |
| Chromosome | 17p13.2 |
| Protein Type | Gene |
| Target Class | Enzyme |
| Function | The enzyme contains a non-heme iron center essential for its catalytic activity and requires iron for proper folding and function. |
| Mechanism of Action | Small molecule inhibitors targeting the active site iron and substrate binding |
| Primary Expression | various tissues including: [@zhang2020] - Brain: Astrocytes, microglia, and cer |
| Druggability | Low (0.38) |
| Clinical Stage | Approved |
| Molecular Weight | ~75 kDa |
| Pathways | Allosteric Binding, Allosteric Binding Sites, Enzyme Dimers, Enzyme Monomer Subunits, Nf-Kb |
| UniProt ID | P16050 |
| GeneCards | ALOX15 |
| Human Protein Atlas | ALOX15 |
| Associated Diseases | ALS, Cancer, Cardiovascular, Cardiovascular Diseases, Fibrosis |
| Known Drugs/Compounds | omega-6 fatty acids, omega-3 fatty acids |
| Interactions | GSDMD, SCD1, HMGCR, TNF, MLKL, ACSL4 |
| SciDEX Target | View Target Profile (7 clinical trials) |
| SciDEX Hypotheses | ALOX15-Driven Enzymatic Ferroptosis in AD Oligoden Astrocytic Lipoxin A4 Pathway Restoration via ALOX |
| KG Connections | 374 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |