Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Cardiovascular: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Cardiovascular is a disease characterized by neurodegeneration research. Key relationships include: therapeutic target, associated with, activates. Associated with Aging, Als, Alzheimer. Connected to 1918 entities in the SciDEX knowledge graph.
| Associated Genes | HSPA1B, AGER, HSPA1A, LRP8, LRP5, LRP1, LRP2, LRP1B |
| KG Connections | 2419 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
HSPG2["HSPG2"] -->|"interacts"| Cardiovascular["Cardiovascular"]
HSPA1B["HSPA1B"] -->|"associated"| Cardiovascular["Cardiovascular"]
AGER["AGER"] -->|"associated"| Cardiovascular["Cardiovascular"]
HSPA1A["HSPA1A"] -->|"associated"| Cardiovascular["Cardiovascular"]
style Cardiovascular fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Inflammation | associated_with | disease | 1.00 |
| Diabetes | associated_with | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| Aging | associated_with | disease | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Epigenetic | therapeutic_target | pathway | 1.00 |
| Heart Failure | associated_with | disease | 1.00 |
| Atherosclerosis | associated_with | disease | 1.00 |
| Metabolic Syndrome | associated_with | disease | 1.00 |
| Stroke | associated_with | disease | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Hypertension | associated_with | disease | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Cardiac | associated_with | disease | 1.00 |
| Senescence | associated_with | disease | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Mtor | therapeutic_target | pathway | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| Cholesterol | regulates | pathway | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Lipid Metabolism | therapeutic_target | pathway | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| Oxidative Stress | regulates | pathway | 1.00 |
| Als | implicated_in | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Inflammation | implicated_in | disease | 1.00 |
| Diabetes | regulates | disease | 1.00 |
| Ischemia | therapeutic_target | disease | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Als | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Obesity | associated_with | disease | 1.00 |
| Als | treats | disease | 1.00 |
| Diabetes | therapeutic_target | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Aging | therapeutic_target | disease | 1.00 |
| Cardiac | regulates | disease | 1.00 |
| Mitophagy | regulates | pathway | 1.00 |
| Als | regulates | disease | 1.00 |
| Aging | activates | disease | 1.00 |
| Cardiac | activates | disease | 1.00 |
| Heart Failure | activates | disease | 1.00 |
| Cardiac | therapeutic_target | disease | 1.00 |
| Myocardial Infarction | therapeutic_target | disease | 1.00 |
| Heart Failure | therapeutic_target | disease | 1.00 |
| Coronary Artery Disease | associated_with | disease | 1.00 |
| Cardiac | inhibits | disease | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MTOR | therapeutic_target | gene | 1.00 |
| DNA | therapeutic_target | gene | 1.00 |
| Als | associated_with | disease | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| Hypertension | associated_with | disease | 1.00 |
| Diabetes | associated_with | disease | 1.00 |
| GENES | associated_with | gene | 1.00 |
| AMPK | therapeutic_target | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| INFLAMMATION | contributes_to | gene | 1.00 |
| NF-ΚB | therapeutic_target | gene | 1.00 |
| AUTOPHAGY | therapeutic_target | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| AGING | therapeutic_target | gene | 1.00 |
| CANCER | contributes_to | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| APOE | activates | gene | 1.00 |
| OXIDATIVE STRESS | regulates | gene | 1.00 |
| AGING | associated_with | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| OXIDATIVE STRESS | therapeutic_target | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| APOPTOSIS | regulates | gene | 1.00 |
| MITOPHAGY | regulates | gene | 1.00 |
| AGING | activates | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | associated_with | gene | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| OXIDATIVE STRESS | associated_with | gene | 1.00 |
| DIABETES MELLITUS | therapeutic_target | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | therapeutic_target | gene | 1.00 |
| AGING | regulates | gene | 1.00 |
| STROKE | associated_with | gene | 1.00 |
| CANCER | causes | gene | 1.00 |
| ALZHEIMER | associated_with | gene | 1.00 |
| ATP | activates | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| STROKE | inhibits | gene | 1.00 |
| GENES | regulates | gene | 1.00 |
| OVERVIEW | therapeutic_target | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Cardiovascular-Neuroinflammatory Dual Targeting | 0.462 | neurodegeneration | Neuroinflammation and microglial priming |
| Cardiovascular-Neuroinflammation Crosstalk Interruption | 0.437 | Alzheimer's disease | Neuroinflammation and microglial priming |
Scientific analyses that reference this entity
clinical neurology | 2026-04-08 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Complement C1q-Targeted Microglial Membrane Camouflaged Nanolipid Carriers for S [PMID:41114949] | Ding YN, Li MQ, Ding PT, Wang P, Guan PP | Nano letters | 2026 | 1 |
| Systemic inflammation as a central player in the initiation and development of A [PMID:40841660] | Bayraktaroglu I, Ortí-Casañ N, Van Dam D | Immunity & ageing : I & A | 2025 | 1 |
| Cerium-doped Prussian blue biomimetic nanozyme as an amplified pyroptosis inhibi [PMID:40050873] | Ma J, Tian Y, Du C, Zhu Y, Huang W, Ding | Journal of nanobiotechnology | 2025 | 1 |
| Interactions between antidiabetes medications and heart-brain axis. [PMID:39639832] | Ong LT, Sia CH | Current opinion in endocrinolo | 2025 | 1 |
| The Molecular Mechanisms of Cognitive Dysfunction in Long COVID: A Narrative Rev [PMID:40507911] | Popa E, Popa AE, Poroch M, Poroch V, Ung | International journal of molec | 2025 | 1 |
| Benzo[a]pyrene promotes gastric cancer progression via activation of the Correa [PMID:41780474] | Tong J, Liu S, Du T, Liu W, Jin Z et al. | Ecotoxicol Environ Saf | 2026 | 0 |
| Alzheimer's disease and inflammatory biomarkers positively correlate in plasma i [PMID:38011580] | Foley KE, Winder Z, Sudduth TL, Martin B | Alzheimers Dement | 2024 | 0 |
| Air pollution, glymphatic impairment, and Alzheimer's disease. [PMID:37777345] | Hussain R, Graham U, Elder A, Nedergaard | Trends in neurosciences | 2023 | 0 |
| Molecular biomarkers for vascular cognitive impairment and dementia. [PMID:37957261] | Hosoki S, Hansra GK, Jayasena T, Poljak | Nature reviews. Neurology | 2023 | 0 |
| Curcumin-Attenuated TREM-1/DAP12/NLRP3/Caspase-1/IL1B, TLR4/NF-κB Pathways, and [PMID:35781221] | Nguyen HD, Jo WH, Hoang NHM, Kim MS | Neurotox Res | 2022 | 0 |
| Age-related molecular changes in the lumbar dorsal root ganglia of mice: Signs o [PMID:33392459] | Vincent K, Dona CPG, Albert TJ, Dahia CL | JOR Spine | 2020 | 0 |
| The beneficial effects of empagliflozin, an SGLT2 inhibitor, on atherosclerosis [PMID:27866224] | Han JH, Oh TJ, Lee G, Maeng HJ, Lee DH e | Diabetologia | 2017 | 0 |
| Sharing pathogenetic mechanisms between acute myocardial infarction and Alzheime [PMID:21098980] | Licastro F, Chiappelli M, Caldarera CM, | J Alzheimers Dis | 2011 | 0 |