| Gene Symbol | ANO3PROTEIN |
| Function | is a member of the anoctamin family of calcium-activated chloride channels (CaCC). |
| Primary Expression | the brain, particularly in the cerebellum, basal ganglia (striatum, globus pallidus), thalamus, and cortical regions |
| Subcellular Localization | </span><span class="infobox-value">Plasma membrane, Cytoplasm, Endoplasmic reticulum</span></div> |
| Amino Acids | 913 aa |
| GeneCards | ANO3PROTEIN |
| Human Protein Atlas | ANO3PROTEIN |
| Transmembrane Architecture | 10 transmembrane helices with a reentrant pore loop between TM3 and TM4, a topology shared with other TMEM16 family members |
| Calcium Sensitivity | Intracellular calcium binding through multiple sites in the N-terminal and loop regions |
| Dimerization | Functional channels require dimerization, with each monomer contributing to the conducting pore |
| Phosphorylation | Multiple serine/threonine phosphorylation sites modulate channel activity |
| Cl- Equilibrium | At resting potentials, ANO3 activation depolarizes neurons toward the Cl- reversal potential (approximately -70 mV in many neurons) |
| Excitability Tuning | By modulating Cl- conductance, ANO3 influences action potential threshold and firing patterns |
| Shunting Inhibition | Increased Cl- conductance can reduce excitatory input effectiveness through shunting |
| Activity-Dependent Activation | Neuronal activity increases intracellular Ca2+, directly activating ANO3 |
| Associated Diseases | ALS, Alzheimer, dementia, neurodegeneration |
| Interactions | RBFOX1 |
| KG Connections | 19 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |