disease

dementia

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about dementia: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7021Connections

0Hypotheses

2Analyses

1Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Accurate diagnosis	Clinical diagnostic accuracy for DLB is only ~50-80%, biomarkers improve this significantly
Differential diagnosis	Helps distinguish DLB from AD, PDD, and other dementias
Disease staging	Biomarkers can track disease progression and severity
Treatment selection	guides medication choices (e.g., cholinesterase inhibitors, antipsychotic sensitivity)
Clinical trial enrichment	Enables identification of appropriate patient populations
Prognostic assessment	Predicts cognitive decline rate and survival outcomes
Associated Genes	SPP1, G3BP1, ALS, LC3, TOLLIP, NBR1, FUS, SQSTM1
KG Connections	202 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    dementia["dementia"] -->|"associated"| neurodegeneration["neurodegeneration"]
    style neurodegeneration fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    LC3["LC3"] -->|"biomarker for"| dementia["dementia"]
    style LC3 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    estrogen_signaling["estrogen signaling"] -->|"protects against"| dementia["dementia"]
    style estrogen_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Alzheimer_s_disease["Alzheimer's disease"] -->|"causes"| dementia["dementia"]
    style Alzheimer_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Tirzepatide["Tirzepatide"] -->|"protects against"| dementia["dementia"]
    style Tirzepatide fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    vascular_dysfunction["vascular dysfunction"] -->|"causes"| dementia["dementia"]
    style vascular_dysfunction fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    style dementia fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (3095)

Target	Relation	Type	Str
neurodegeneration	associated_with	process	0.70

Incoming (3926)

Source	Relation	Type	Str
LC3	biomarker_for	protein	0.80
estrogen signaling	protects_against	pathway	0.75
Alzheimer's disease	causes	disease	0.70
Tirzepatide	protects_against	drug	0.70
vascular dysfunction	causes	process	0.70
Alzheimer's disease	associated_with	disease	0.70
PD_ProS	associated_with	phenotype	0.64
MAPT	associated_with	gene	0.60
APP	associated_with	gene	0.60
MAPK	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
TFEB	associated_with	protein	0.60
NLRP3	associated_with	protein	0.60
SIRT3	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
LRP1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
TNF	associated_with	gene	0.60
TBK1	associated_with	gene	0.60
TGM2	associated_with	gene	0.60
CD4	associated_with	gene	0.60
CHMP2B	associated_with	gene	0.60
NES	associated_with	protein	0.60
FUS	associated_with	gene	0.60
NPTX2	associated_with	protein	0.60
GFAP	associated_with	gene	0.60
GJA1	associated_with	gene	0.60
VCAM1	associated_with	gene	0.60
CCL2	associated_with	protein	0.60
CD44	associated_with	gene	0.60
CXCR4	associated_with	gene	0.60
ATP	associated_with	protein	0.60
TAF15	associated_with	protein	0.60
PSP	associated_with	gene	0.60
ELAVL4	associated_with	gene	0.60
CX3CL1	associated_with	gene	0.60
CX3CR1	associated_with	gene	0.60
OPA1	associated_with	protein	0.60
AMPK	associated_with	protein	0.60
STING	associated_with	gene	0.60
APOE3	associated_with	protein	0.60
RELN	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
ATXN3	associated_with	gene	0.60
ATG14	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

neurodegeneration | 2026-04-14 | 0 hypotheses

What are the specific molecular mechanisms by which C1Q components drive atheros

neuroinflammation | 2026-04-07 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

dementia

Understanding Entity Pages

Wiki Pages (21)

Dementia with Lewy Bodies Biomarkers

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

Atypical Parkinsonism

CBS/PSP Rehabilitation Master Guide

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

PD Combination Therapy Matrix

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

Neuroresilience Mechanisms and Evidence