Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ALZHEIMER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ALZHEIMER is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 3570 entities in the SciDEX knowledge graph.
| Gene Symbol | ALZHEIMER |
| Summary | Page for Hippocampal CA3 Pyramidal Neurons in Alzheimer's Disease |
| Associated Diseases | ALS, ALZHEIMER'S, ALZHEIMER'S DISEASE, Aging, Alzheimer |
| Known Drugs/Compounds | RAPAMYCIN, MEMANTINE, LECANEMAB, RESVERATROL, CURCUMIN, METFORMIN |
| Interactions | BACE1, CYTOKINES, NEURODEGENERATIVE DISORDERS, REELIN, IBA1, TNF |
| KG Connections | 9339 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
subgraph Pathology["Pathology"]
ALZHEIMER["ALZHEIMER"] -->|"associated with"| MICROGLIA["MICROGLIA"]
ALZHEIMER["ALZHEIMER"] -->|"associated with"| NEURON["NEURON"]
ALZHEIMER["ALZHEIMER"] -->|"associated with"| MITOCHONDRIA["MITOCHONDRIA"]
ALZHEIMER["ALZHEIMER"] -->|"associated with"| Alzheimer_1["Alzheimer"]
ALZHEIMER["ALZHEIMER"] -->|"associated with"| APOE["APOE"]
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated with"| ALZHEIMER["ALZHEIMER"]
OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"associated with"| ALZHEIMER["ALZHEIMER"]
end
subgraph Signaling["Signaling"]
ALZHEIMER["ALZHEIMER"] -->|"activates"| CYTOKINES["CYTOKINES"]
ALZHEIMER["ALZHEIMER"] -->|"activates"| NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
ALZHEIMER["ALZHEIMER"] -.->|"inhibits"| Alzheimer["Alzheimer"]
ROS["ROS"] -->|"activates"| ALZHEIMER["ALZHEIMER"]
COMPLEMENT["COMPLEMENT"] -->|"activates"| ALZHEIMER["ALZHEIMER"]
AMPK["AMPK"] -->|"activates"| ALZHEIMER["ALZHEIMER"]
TREM2["TREM2"] -->|"activates"| ALZHEIMER["ALZHEIMER"]
end
subgraph Interactions["Interactions"]
ALZHEIMER["ALZHEIMER"] -->|"protects against"| Alzheimer_2["Alzheimer"]
end
style ALZHEIMER fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style MICROGLIA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NEURON fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MITOCHONDRIA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style CYTOKINES fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NEURODEGENERATIVE_DISORDERS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Alzheimer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Alzheimer_1 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style APOE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Alzheimer_2 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style ROS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style ALZHEIMER_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style COMPLEMENT fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AMPK fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style OXIDATIVE_STRESS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style TREM2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Complement | activates | pathway | 1.00 |
| Senescence | associated_with | disease | 1.00 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 1.00 |
| Immune Response | therapeutic_target | pathway | 1.00 |
| Epigenetic | activates | pathway | 1.00 |
| Blood-Brain Barrier | therapeutic_target | pathway | 1.00 |
| Lipid Metabolism | associated_with | pathway | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Lipid Metabolism | regulates | pathway | 1.00 |
| Dementia | associated_with | disease | 1.00 |
| Lipid Metabolism | therapeutic_target | pathway | 1.00 |
| Blood-Brain Barrier | associated_with | pathway | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Mtor | associated_with | pathway | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Oxidative Stress | regulates | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Mitochondrial Function | therapeutic_target | pathway | 1.00 |
| Mtor | therapeutic_target | pathway | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| Immune Response | regulates | pathway | 1.00 |
| Apoptosis | inhibits | pathway | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Autophagy | inhibits | pathway | 1.00 |
| Mitophagy | therapeutic_target | pathway | 1.00 |
| Synaptic Plasticity | activates | pathway | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Synaptic Plasticity | therapeutic_target | pathway | 1.00 |
| Apoptosis | associated_with | pathway | 1.00 |
| Inflammasome | activates | pathway | 1.00 |
| Epigenetic | associated_with | pathway | 1.00 |
| Blood-Brain Barrier | activates | pathway | 1.00 |
| MICROGLIA | associated_with | gene | 1.00 |
| NEURON | associated_with | gene | 1.00 |
| MITOCHONDRIA | associated_with | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| NEURODEGENERATIVE DISORDERS | activates | gene | 1.00 |
| Alzheimer | inhibits | disease | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| APOE | associated_with | gene | 1.00 |
| Alzheimer | protects_against | disease | 1.00 |
| DEPRESSION | associated_with | gene | 1.00 |
| Depression | associated_with | disease | 1.00 |
| AGING | causes | gene | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOE | therapeutic_target | gene | 1.00 |
| APOE | associated_with | gene | 1.00 |
| APOE | activates | gene | 1.00 |
| TREM2 | regulates | gene | 1.00 |
| MTOR | activates | gene | 1.00 |
| LC3 | activates | gene | 1.00 |
| OVERVIEW | associated_with | gene | 1.00 |
| TREM2 | activates | gene | 1.00 |
| OVERVIEW | therapeutic_target | gene | 1.00 |
| TREM2 | associated_with | gene | 1.00 |
| MTOR | associated_with | gene | 1.00 |
| APP | activates | gene | 1.00 |
| GFAP | biomarker_for | gene | 1.00 |
| NFL | biomarker_for | gene | 1.00 |
| APP | therapeutic_target | gene | 1.00 |
| BDNF | activates | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| MTOR | therapeutic_target | gene | 1.00 |
| NRF2 | activates | gene | 1.00 |
| APP | associated_with | gene | 1.00 |
| APOE | regulates | gene | 1.00 |
| TREM2 | therapeutic_target | gene | 1.00 |
| APOE | expressed_in | gene | 1.00 |
| TREM2 | expressed_in | gene | 1.00 |
| TREM2 | implicated_in | entity | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| Depression | associated_with | disease | 1.00 |
| DNA | associated_with | gene | 1.00 |
| Dementia | associated_with | disease | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| APOE4 | expressed_in | gene | 1.00 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 1.00 |
| DNA | therapeutic_target | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| Stroke | associated_with | disease | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| GENES | associated_with | gene | 1.00 |
| Diabetes | associated_with | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| GENES | regulates | gene | 1.00 |
| Cardiovascular | associated_with | disease | 1.00 |
| AKT | regulates | gene | 1.00 |
| Huntington | associated_with | disease | 1.00 |
| APOE4 | associated_with | gene | 1.00 |
| P62 | activates | gene | 1.00 |
| Tauopathy | associated_with | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| DNA | regulates | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.675
neurodegeneration | 2026-04-16 | 2 hypotheses Top: 0.608
neurodegeneration | 2026-04-16 | 0 hypotheses
connectomics | 2026-04-16 | 0 hypotheses
lipidomics | 2026-04-16 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| External fixation versus reverse shoulder arthroplasty for proximal humerus frac [PMID:41940987] | Vadalà A, Benelli C, Suraci F, Carta B, | Arch Orthop Trauma Surg | 2026 | 0 |
| Gray matter structural and molecular signatures in Alzheimer's disease and late- [PMID:41419068] | Yang S, Wang X, Yan Y, Zhang J, Wei Y et | J Affect Disord | 2026 | 0 |
| Cytomegalic parvalbumin neurons in fetal cases of hemimegalencephaly. [PMID:39973610] | Gelot AB, Draia-Nicolau TO, Mathieu R, S | Epilepsia | 2025 | 0 |
| Brain connectivity and transcriptional changes induced by rTMS in first-episode [PMID:40274783] | Guan M, Xie Y, Wang Z, Miao Y, Li X et a | Transl Psychiatry | 2025 | 0 |
| Single-cell RNA sequencing of adult primate neocortex reveals the regulatory dyn [PMID:40385068] | Zhang C, Xie Z, Wang N | Am J Transl Res | 2025 | 0 |
| Human stem cell-derived GABAergic interneuron development reveals early emergenc [PMID:40651475] | Bershteyn M, Zhou H, Fuentealba L, Chen | Neuron | 2025 | 0 |
| Enhancer AAV toolbox for accessing and perturbing striatal cell types and circui [PMID:40403704] | Hunker AC, Wirthlin ME, Gill G, Johansen | Neuron | 2025 | 0 |
| Forebrain assembloids support the development of fast-spiking human PVALB+ corti [PMID:40695284] | Walsh RM, Crabtree GW, Kalpana K, Jubier | Neuron | 2025 | 0 |
| Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social [PMID:40320404] | Qi C, Sima W, Mao H, Hu E, Ge J et al. | Nat Commun | 2025 | 0 |
| Distinct dendritic integration strategies control dynamics of inhibition in the [PMID:40592329] | Morabito A, Zerlaut Y, Dhanasobhon D, Be | Neuron | 2025 | 0 |
| Targeting SARM1 improves autophagic stress-induced axonal neuropathy. [PMID:37561040] | Kim HR, Lee HJ, Jeon Y, Jang SY, Shin YK | Autophagy | 2024 | 0 |
| Integrated multimodal cell atlas of Alzheimer's disease. [PMID:39402379] | Gabitto MI, Travaglini KJ, Rachleff VM, | Nat Neurosci | 2024 | 0 |
| Identification of early Alzheimer's disease subclass and signature genes based o [PMID:39650656] | Wang W, Lu J, Pan N, Zhang H, Dai J et a | Front Immunol | 2024 | 0 |
| Cortical somatostatin long-range projection neurons and interneurons exhibit div [PMID:38086373] | Fisher J, Verhagen M, Long Z, Moissidis | Neuron | 2024 | 0 |
| Locus Coeruleus-Dorsolateral Septum Projections Modulate Depression-Like Behavio [PMID:38155473] | Zhang Q, Xue Y, Wei K, Wang H, Ma Y et a | Adv Sci (Weinh) | 2024 | 0 |
| Somatostatin and the pathophysiology of Alzheimer's disease. [PMID:38484981] | Almeida VN | Ageing Res Rev | 2024 | 0 |
| Somatostatin interneurons control the timing of developmental desynchronization [PMID:38599213] | Mòdol L, Moissidis M, Selten M, Oozeer F | Neuron | 2024 | 0 |
| De novo gene synthesis by an antiviral reverse transcriptase. [PMID:39116258] | Tang S, Conte V, Zhang DJ, Žedaveinytė R | Science | 2024 | 0 |
| Signature morphoelectric properties of diverse GABAergic interneurons in the hum [PMID:37824669] | Lee BR, Dalley R, Miller JA, Chartrand T | Science | 2023 | 0 |
| Novel App knock-in mouse model shows key features of amyloid pathology and revea [PMID:35690868] | Xia D, Lianoglou S, Sandmann T, Calvert | Mol Neurodegener | 2022 | 0 |