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ALZHEIMER

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALZHEIMER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14100Connections

30Hypotheses

0Analyses

50Outgoing

50Incoming

15Experiments

0Debates

Summary

🤖 AI-Generated

ALZHEIMER is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 3570 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ALZHEIMER
Function	ALZHEIMER participates in multiple biological pathways relevant to neurodegeneration:
Inflammation Regulation	Inhibits both general Inflammation and Neuroinflammation (strength: 1.00)
Senescence Association	Associated with cellular Senescence processes (strength: 1.00)
Aging Modulation	Exhibits inhibitory effects on Aging (strength: 1.00)
Pathway Activation	Activates the Complement pathway (strength: 1.00)
Neurodegeneration Activation	Activates both NEURODEGENERATIVE DISEASES and NEURODEGENERATIVE DISORDERS genes (strength: 1.00)
Associated Diseases	aging, Als, Alzheimer, Alzheimer Disease
Known Drugs/Compounds	ADUCANUMAB, CURCUMIN, LECANEMAB, MELATONIN, MEMANTINE, METFORMIN
Interactions	A2M, AADC, ABCA1, ABCA7, ABCD3, ABI3
KG Connections	8664 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ALZHEIMER

gene · 579 words

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ALZHEIMER

disease · 2162 words

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Pathway Diagram

graph TD
    subgraph Pathology["Pathology"]
        ALZHEIMER["ALZHEIMER"] -->|"associated with"| MICROGLIA["MICROGLIA"]
        ALZHEIMER["ALZHEIMER"] -->|"associated with"| NEURON["NEURON"]
        ALZHEIMER["ALZHEIMER"] -->|"associated with"| MITOCHONDRIA["MITOCHONDRIA"]
        ALZHEIMER["ALZHEIMER"] -->|"associated with"| Alzheimer_1["Alzheimer"]
        ALZHEIMER["ALZHEIMER"] -->|"associated with"| APOE["APOE"]
        ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated with"| ALZHEIMER["ALZHEIMER"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"associated with"| ALZHEIMER["ALZHEIMER"]
    end
    subgraph Signaling["Signaling"]
        ALZHEIMER["ALZHEIMER"] -->|"activates"| CYTOKINES["CYTOKINES"]
        ALZHEIMER["ALZHEIMER"] -->|"activates"| NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
        ALZHEIMER["ALZHEIMER"] -.->|"inhibits"| Alzheimer["Alzheimer"]
        ROS["ROS"] -->|"activates"| ALZHEIMER["ALZHEIMER"]
        COMPLEMENT["COMPLEMENT"] -->|"activates"| ALZHEIMER["ALZHEIMER"]
        AMPK["AMPK"] -->|"activates"| ALZHEIMER["ALZHEIMER"]
        TREM2["TREM2"] -->|"activates"| ALZHEIMER["ALZHEIMER"]
    end
    subgraph Interactions["Interactions"]
        ALZHEIMER["ALZHEIMER"] -->|"protects against"| Alzheimer_2["Alzheimer"]
    end
    style ALZHEIMER fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style MICROGLIA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style NEURON fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style MITOCHONDRIA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style CYTOKINES fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style NEURODEGENERATIVE_DISORDERS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer_1 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style APOE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer_2 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ROS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style COMPLEMENT fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AMPK fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style OXIDATIVE_STRESS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style TREM2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0

Outgoing (6476)

Target	Relation	Type	Str
Complement	activates	pathway	1.00
Aging	inhibits	disease	1.00
NEURODEGENERATIVE DISEASES	activates	gene	1.00
Alzheimer	activates	disease	1.00
Alzheimer	biomarker_for	disease	1.00
Neuroinflammation	inhibits	disease	1.00
NEURODEGENERATIVE DISORDERS	activates	gene	1.00
Alzheimer	interacts_with	disease	1.00
AGING	causes	gene	1.00
Dementia	activates	disease	1.00
ALZHEIMER'S DISEASE	interacts_with	gene	1.00
AMYLOID	interacts_with	gene	1.00
Aging	causes	disease	1.00
Senescence	associated_with	disease	1.00
CYTOKINES	activates	gene	1.00
Synaptic Plasticity	therapeutic_target	pathway	1.00
Apoptosis	inhibits	pathway	1.00
Autophagy	inhibits	pathway	1.00
Alzheimer	inhibits	disease	1.00
Inflammasome	activates	pathway	1.00
Alzheimer	protects_against	disease	1.00
Apoptosis	activates	pathway	1.00
Autophagy	therapeutic_target	pathway	1.00
Alzheimer	causes	disease	1.00
Blood-Brain Barrier	activates	pathway	1.00
Oxidative Stress	regulates	pathway	1.00
Oxidative Stress	therapeutic_target	pathway	1.00
Mtor	therapeutic_target	pathway	1.00
Senescence	associated_with	disease	1.00
Mitophagy	therapeutic_target	pathway	1.00
Autophagy	associated_with	pathway	1.00
Lipid Metabolism	regulates	pathway	1.00
Nf-Κb	activates	pathway	1.00
Synaptic Plasticity	activates	pathway	1.00
Complement	activates	pathway	1.00
Apoptosis	therapeutic_target	pathway	1.00
Immune Response	regulates	pathway	1.00
Lipid Metabolism	associated_with	pathway	1.00
Amyotrophic Lateral Sclerosis	associated_with	disease	1.00
Immune Response	activates	pathway	1.00
Mtor	activates	pathway	1.00
Mitophagy	activates	pathway	1.00
Immune Response	therapeutic_target	pathway	1.00
Autophagy	activates	pathway	1.00
Lipid Metabolism	therapeutic_target	pathway	1.00
Epigenetic	activates	pathway	1.00
Oxidative Stress	activates	pathway	1.00
Blood-Brain Barrier	therapeutic_target	pathway	1.00
Mitochondrial Function	therapeutic_target	pathway	1.00
Inflammation	inhibits	disease	1.00

Incoming (7624)

Source	Relation	Type	Str
TLR4	activates	gene	1.00
PINK1	activates	gene	1.00
PI3K	therapeutic_target	gene	1.00
APOE4	activates	gene	1.00
STAT3	activates	gene	1.00
OVERVIEW	activates	gene	1.00
AMPK	activates	gene	1.00
AKT	activates	gene	1.00
APP	inhibits	gene	1.00
AKT	therapeutic_target	gene	1.00
MIRNAS	therapeutic_target	gene	1.00
APP	protects_against	gene	1.00
NLRP3	activates	gene	1.00
GENES	expressed_in	gene	1.00
DNA	associated_with	gene	1.00
APP	regulates	gene	1.00
DNA	regulates	gene	1.00
LC3	activates	gene	1.00
APOE4	expressed_in	gene	1.00
DNA	activates	gene	1.00
GENES	regulates	gene	1.00
Diabetes	associated_with	disease	1.00
P62	activates	gene	1.00
TNF	activates	gene	1.00
MTOR	therapeutic_target	gene	1.00
AKT	regulates	gene	1.00
PI3K	activates	gene	1.00
NRF2	activates	gene	1.00
Tauopathy	associated_with	disease	1.00
TREM2	expressed_in	gene	1.00
TREM2	associated_with	gene	1.00
APOE	expressed_in	gene	1.00
TREM2	therapeutic_target	gene	1.00
APOE	regulates	gene	1.00
APOE	activates	gene	1.00
GENES	therapeutic_target	gene	1.00
TREM2	regulates	gene	1.00
MTOR	activates	gene	1.00
TREM2	activates	gene	1.00
GFAP	biomarker_for	gene	1.00
GENES	activates	gene	1.00
DNA	therapeutic_target	gene	1.00
APP	activates	gene	1.00
APOE	therapeutic_target	gene	1.00
OVERVIEW	therapeutic_target	gene	1.00
MTOR	associated_with	gene	1.00
NFL	biomarker_for	gene	1.00
APP	therapeutic_target	gene	1.00
BDNF	activates	gene	1.00
APP/PS1	activates	gene	1.00

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound targeting EC-II	0.968	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.955	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.912	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.865	alzheimers	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.865	alzheimers	Circuit-level neural dynamics in neurode

TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxic	0.847	neurodegeneration	Legacy Pre-Pipeline Hypothesis Import
Closed-loop transcranial focused ultrasound to restore hippo	0.827	alzheimers	Circuit-level neural dynamics in neurode
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive	0.801	alzheimers	Cell type vulnerability in Alzheimers Di
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.797	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.784	alzheimers	Circuit-level neural dynamics in neurode
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo	0.779	alzheimers	Cell type vulnerability in Alzheimers Di
Complement C1q-Mediated Synaptic Pruning Drives Early Cognit	0.769	neurodegeneration	Legacy Pre-Pipeline Hypothesis Import
Closed-loop transcranial focused ultrasound to restore hippo	0.767	alzheimers	Circuit-level neural dynamics in neurode
C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV I	0.747	neurodegeneration	Are interneuron oscillation deficits com
Regional TREM2-Dependent Lipid Metabolism Determines Cortica	0.721	neuroinflammation	How do regional, age, and sex-dependent
Excessive C1q/C3/CR3 complement cascade activation initiates	0.720	neurodegeneration	Synaptic pruning by microglia in neurode
Complement C1q/C3 Inhibition to Prevent Synaptodendritis in	0.690	neurodegeneration	Test
TREM2-Dependent Microglial State Transition as Therapeutic W	0.690	neurodegeneration	Gap 006 analysis (archived stub)
ISR/eIF2α~P Overflow Represses Synaptic Protein Synthesis Do	0.683	alzheimers	-
NMN Adenosine Transport Enhancement for Cortical Neuron Sene	0.680	neurodegeneration	-
Dasatinib plus Quercetin Senolytic Clearance of p16Ink4a-Hig	0.680	neurodegeneration	-
TREM2 Agonism to Promote Neuroprotective Microglial Phenotyp	0.670	neurodegeneration	Test
Agonistic antibodies targeting TREM2 to shift microglia towa	0.660	neurodegeneration	Test
TDP-43 Liquid-Liquid Phase Separation Dominance in Stress Gr	0.650	alzheimers	-
TREM2-dependent microglial lipid handling in Alzheimer's dis	0.650	neurodegeneration	Test
Endothelial miR-181c-5p Upregulation Drives Claudin-5 Repres	0.645	-	What blood-brain barrier permeability ch
TREM2 Agonism for Alzheimer's Disease	0.636	neurodegeneration	Test
LAMP2A Upregulation to Enhance Chaperone-Mediated Autophagy	0.000	proteomics	Quantitative proteomics of the aging syn
Closed-loop transcranial focused ultrasound to restore hippo	0.000	alzheimers	Circuit-level neural dynamics in neurode
Cell-Type-Specific TFEB Modulation Combined with Trehalose f	0.000	proteomics	Quantitative proteomics of the aging syn

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (15)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Plant-based dietary patterns and Alzheimer's disease risk in multiethn	clinical	Alzheimer's disease and relate	0.950	0.00	human patients	proposed	N/A
SIRPα modulation in mouse models of Alzheimer's disease	validation	Alzheimer's disease	0.900	0.00	mouse models of Alzheimer's di	proposed	N/A
Epigenetic clocks association with brain aging patterns in older women	exploratory	cognitive impairment and demen	0.900	0.00	human patients	proposed	N/A
Microglial SIRPα expression in human Alzheimer's disease tissue	exploratory	Alzheimer's disease	0.800	0.00	human brain tissue	proposed	N/A
Closed-loop tFUS Enhances Glymphatic Clearance and Restores CA1 PV Int	in_vivo	Alzheimer's disease	0.765	0.55	APP/PS1 mice 8-11 months (n=10	abandoned	$125,000
Single nuclei transcriptomic and epigenomic profiling of 84 donors acr	gene_expression	Alzheimer's disease	0.500	0.00	human	extracted	N/A
The Seattle Alzheimer's Disease Brain Cell Atlas (SEA-AD) integrates n	neuropathology	Alzheimer's disease	0.500	0.00	human	extracted	N/A
In late life, NfL demonstrated the strongest association with incident	clinical	Alzheimer's disease	0.500	0.00	human	extracted	N/A
Complex gene expression differences were identified, ranging from glob	gene_expression	Alzheimer's disease	0.500	0.00	post_mortem_brain	extracted	N/A
A subset of donors with particularly severe cellular and molecular phe	clinical	Alzheimer's disease	0.500	0.00	human	extracted	N/A
Midlife hypertension was associated with 0.15-SD faster NfL increase a	clinical	Alzheimer's disease	0.500	0.00	human	extracted	N/A
A subset of donors exhibited particularly severe cellular and molecula	computational	Alzheimer's disease	0.500	0.00	human	extracted	N/A
Cell type-specific analysis identified early-phase loss of somatostati	gene_expression	Alzheimer's disease	0.500	0.00	human	extracted	N/A
Single-cell/multiomics analysis of 84 human post-mortem brains reveale	computational	Alzheimer's disease	0.500	0.00	human	extracted	N/A
Temporal analysis of gene expression differences across disease progre	gene_expression	Alzheimer's disease	0.500	0.00	human	extracted	N/A

Related Papers (10)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Retinal Müller glia alterations and their impact on ocular glymphatic clearance [PMID:41603340]	Das G, Raghunathan R, Wang L	J Alzheimers Dis	2026
The Glymphatic-Venous Axis in Brain Clearance Failure: Aquaporin-4 Dysfunction, [PMID:41226584]	["Costea D", "Dobrin N", "Tataru C", "To	International journal of molec	2025
Longitudinal changes of blood-brain barrier and transcytolemmal water exchange p [PMID:40089221]	Xiong C, Yu Z, Yin Y	Neuroimage	2025
The future of biomarkers for vascular contributions to cognitive impairment and [PMID:40542975]	Lennon MJ, Karvelas N, Ganesh A	Geroscience	2025
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667]	Zhang D, Zhang W, Ming C, Gao X, Yuan H,	Neuron	2024
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117]	Balusu S, De Strooper B	Acta neuropathologica	2024
Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890]	Burillo J, Marqués P, Jiménez B, Gonzále	Cells	2021
Improvement of glymphatic-lymphatic drainage of beta-amyloid by focused ultrasou [PMID:32999351]	Lee Y, Choi Y, Park EJ	Sci Rep	2020
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169]	["Oakley, Holly", "Cole, Sarah L", "Loga	The Journal of neuroscience :	2006
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773]	["Hardy, John", "Selkoe, Dennis J"]	Science (New York, N.Y.)	2002

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ALZHEIMER in their description or question text

ALZHEIMER

Understanding Entity Pages

Summary

Wiki Pages (2)

ALZHEIMER

ALZHEIMER

Pathway Diagram

Outgoing (6476)

Incoming (7624)

Targeting Hypotheses (30)

Mentioning Analyses (0)

Experiments (15)

Related Papers (10)

Debates (0)

Related Research

TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxicity in Alzheimer's D

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Degen

Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with r

Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activa

ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes Underlie

Complement C1q-Mediated Synaptic Pruning Drives Early Cognitive Decline in Alzhe

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV Interneuron Input Eli

Regional TREM2-Dependent Lipid Metabolism Determines Cortical Vulnerability in A

Excessive C1q/C3/CR3 complement cascade activation initiates pre-symptomatic syn

Complement C1q/C3 Inhibition to Prevent Synaptodendritis in Alzheimer's Disease

TREM2-Dependent Microglial State Transition as Therapeutic Window in Alzheimer's