protein 819 words KG: C4APROTEIN 2026-03-20
kind:proteinsection:proteinsstate:published
Contents

C4A Protein (Complement Component 4A)

🔬 Protein Info
Gene SymbolC4A
Full NameC4A (Complement Component 4A)
AliasesComplement component C4A gene, Complement Component 4A
Chromosome6p21.3
Protein TypeProtein
Functionencodes a critical protein in the classical complement cascade, a key component of the innate immune system.
Molecular Weight104 kDa
Amino Acids1741 aa
UniProt IDP0C0P0
NCBI Gene ID712
Ensembl IDENSG00000144711
OMIM120810
GeneCardsC4A
Human Protein AtlasC4A
Associated DiseasesALS
InteractionsC4B, PSP, C4
KG Connections37 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (11)

Age-Dependent Complement C4b Upregulation Drives Synaptic Vu
Score: 0.47
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.43
Complement-Mediated Synaptic Pruning Dysregulation
Score: 0.40
SASP-Mediated Complement Cascade Amplification
Score: 0.70
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56

Related Analyses (11)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Key Papers (1)

Schizophrenia risk from complex variation of complement component 4.
Nature 2016

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in