protein 1,112 words KG: CATHEPSINB 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

Cathepsin B Protein

🔬 Protein Info
Gene SymbolCTSB
Full NameCathepsin B
Chromosome8p23.1
Protein FamilyCysteine cathepsin family (papain-like)
Subcellular LocalizationLysosomes, endosomes
Molecular Weight38 kDa (339 amino acids)
Amino Acids339 aa
Exons13
PathwaysAutophagy
UniProt IDP07846
NCBI Gene ID1508
Ensembl IDENSG00000164733
OMIM116810
GeneCardsCTSB
Human Protein AtlasCTSB
Associated DiseasesALS, APOPTOSIS, Aging, Alzheimer, Amyotrophic Lateral Sclerosis
Known Drugs/Compoundsrapamycin, tannic acid
InteractionsC1QA, SPP1, GRN, CALCINEURIN, ATG12, ATG10
KG Connections853 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Microbial Inflammasome Priming Prevention
Score: 0.58
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
Lysosomal Membrane Repair Enhancement
Score: 0.45
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.43

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (1)

s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40

See Also (15)

LRRK2 G2019S Transgenic Mouse Model
model · KG edge: associated_with
TLR2 — Toll-Like Receptor 2
gene · KG edge: expressed_in
Microglia in Neurodegeneration
entity · KG edge: associated_with
Neurodegeneration
disease · KG edge: implicated_in
Transdiagnostic Proteomic Changes in Neurodegeneration
mechanism · Pages share 5 hypotheses

Knowledge Graph (3 edges)

CATHEPSINB associated_with LRRK2
TLR2 expressed_in CATHEPSINB
MICROGLIA associated_with CATHEPSINB