protein 1,112 words KG: CATHEPSINB
Contents

Cathepsin B Protein

🔬 Protein Info
Gene SymbolCATHEPSINB
Full NameCathepsin B
Protein FamilyCysteine cathepsin family (papain-like)
Protein TypeProtease
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionvarious cell types throughout the brain:
Molecular Weight38 kDa (339 amino acids)
Amino Acids339 aa
UniProt IDP07846
GeneCardsCATHEPSINB
Human Protein AtlasCATHEPSINB
Associated Diseasesneurodegeneration
KG Connections3 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (8)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Microbial Inflammasome Priming Prevention
Score: 0.65
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Lysosomal Membrane Repair Enhancement
Score: 0.54
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (1)

s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40

See Also (15)

Microglia in Neurodegeneration
entity · KG edge: associated_with
Neurodegeneration
disease · KG edge: implicated_in
TLR2 — Toll-Like Receptor 2
gene · KG edge: expressed_in
LRRK2 G2019S Transgenic Mouse Model
model · KG edge: associated_with
Endosomal-Lysosomal Pathway in Neurodegeneration
mechanism · Pages share 5 hypotheses

Knowledge Graph (3 edges)

TLR2 expressed_in CATHEPSINB
CATHEPSINB associated_with LRRK2
MICROGLIA associated_with CATHEPSINB

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