gene 884 words KG: TLR2 2026-03-24
kind:genesection:genesstate:published
Contents

TLR2 — Toll-Like Receptor 2

🧬 Gene Info
Gene SymbolTLR2
Full NameToll-Like Receptor 2
Chromosome4q31.3
Protein TypeReceptor
FunctionTLR2 is expressed in microglia, astrocytes, and neurons throughout the brain.
Primary Expressionmicroglia, astrocytes, and neurons throughout the brain
Amino Acids784 aa
Exons3
PathwaysNF-κB, PI3K
UniProt IDQ9Y257
NCBI Gene ID7103
Ensembl IDENSG00000137462
OMIM603028
GeneCardsTLR2
Human Protein AtlasTLR2
Associated DiseasesALS, Alzheimer, Brain Injury, Fibrosis, Inflammation
Known Drugs/CompoundsC29
InteractionsCMKLR1, RAGE, NFKBIA, MRC1, IL1B, ITGAM
KG Connections702 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (20)

TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.62
Microbial Inflammasome Priming Prevention
Score: 0.58
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56

Related Analyses (9)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

Related Experiments (4)

Longitudinal TLR2 reporter gene study in α-synuclein mice
validation · proposed · Score: 0.90
TLR expression analysis in Parkinson's disease patients
clinical · proposed · Score: 0.85
TLR expression in α-synuclein overexpressing mice
validation · proposed · Score: 0.80
NLRP3 Inflammasome Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (4)

Alzheimer Indonesia
institution · KG edge: associated_with
AIFM1 Gene
gene · KG edge: expressed_in
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates

Knowledge Graph (12 edges)

TLR2 regulates C3
TLR2 therapeutic_target MTOR
TLR2 therapeutic_target BID
TLR2 therapeutic_target BAD
TLR2 associated_with CD36
TLR2 interacts_with CMKLR1
TLR2 interacts_with RAGE
TLR2 associated_with TLR4
TLR2 associated_with CD14
TLR2 regulates CXCL1