| Gene Symbol | CBLN2PROTEIN |
| Function | is a member of the Cerebellin family of secreted proteins that play crucial roles in synaptic connectivity and neuronal communication in the central nervous system. |
| Primary Expression | both cerebellar and extra-cerebellar regions |
| Subcellular Localization | ** | Secreted, extracellular matrix | |
| Molecular Weight | 32 kDa |
| GeneCards | CBLN2PROTEIN |
| Human Protein Atlas | CBLN2PROTEIN |
| Signal Peptide | N-terminal secretory signal sequence for extracellular targeting |
| Cerebellin Domain | Core domain mediating protein-protein interactions |
| Dimerization Capacity | Forms homodimers and heterodimers with other CBLN family members |
| Post-translational Modifications | Contains potential N-glycosylation sites for extracellular stability |
| Presynaptic Organization | Binds to presynaptic neurexin-1 isoforms to induce presynaptic differentiation |
| Postsynaptic Targeting | Recruits postsynaptic density proteins and glutamate receptors to synaptic sites |
| Synapse Maintenance | Contributes to long-term stability of established synapses |
| Excitatory Specificity | Primarily promotes glutamatergic excitatory synapses |
| Associated Diseases | neurodegeneration |
| Interactions | GLUD1, GRID1, Rb, SYNAPSE |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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