gene

GLUD1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLUD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

118Connections
0Hypotheses
0Analyses
50Outgoing
37Incoming

Summary

GLUD1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, activates, therapeutic target. Associated with Als, Anxiety, Cancer. Connected to 60 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolGLUD1
Full NameGlutamate Dehydrogenase 1
AliasesPage for GLUD1
Chromosome10q23.3
Protein TypeEnzyme
FunctionGLUD1 is a mitochondrial matrix enzyme belonging to the glutamate dehydrogenase family
Primary ExpressionLiver, kidney, brain, pancreas
Amino Acids505 aa
PathwaysGlycolysis, Histone Modification, Mtor, Oxidative Phosphorylation, Oxidative Stress
UniProt ID[P00341](https://www.uniprot.org/uniprot/P00341)
Ensembl IDENSG00000148671
OMIM130120
GeneCardsGLUD1
Human Protein AtlasGLUD1
N-terminal antenna regionContains the allosteric binding sites
Associated DiseasesParkinson, Parkinson'S Disease
InteractionsLAMP1, PRKCD, CBLN1, BECN1, NRG1, NLGN2
KG Connections118 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

GLUD1 - Glutamate Dehydrogenase 1

gene · 1083 words

CBLN1 Gene

gene · 1688 words

Ubiquitin-Proteasome System Therapeutic Companies for Parkinson's Disease

company · 1660 words

Metabolic-Epigenetic Axis in Neurodegeneration Synthesis

mechanism · 1658 words

SIRT5 - Sirtuin 5

gene · 1536 words

GLUD2 Gene

gene · 1253 words

Pathway Diagram

graph TD
    GLUD1["<b>GLUD1</b>"]
    Ms{"Ms"}
    GLUD1 -->|"inhibits"| Ms
    Als{"Als"}
    GLUD1 -->|"inhibits"| Als
    Anxiety{"Anxiety"}
    GLUD1 -->|"inhibits"| Anxiety
    Schizophrenia{"Schizophrenia"}
    GLUD1 -->|"inhibits"| Schizophrenia
    Parkinson{"Parkinson"}
    GLUD1 -->|"therapeutic target"| Parkinson
    LAMP1["LAMP1"]
    GLUD1 -->|"inhibits"| LAMP1
    PRKCD["PRKCD"]
    GLUD1 -->|"inhibits"| PRKCD
    CBLN1["CBLN1"]
    GLUD1 -->|"interacts with"| CBLN1
    BECN1["BECN1"]
    GLUD1 -->|"inhibits"| BECN1
    Autophagy(["Autophagy"])
    GLUD1 -->|"inhibits"| Autophagy
    NRG1["NRG1"]
    GLUD1 -->|"inhibits"| NRG1
    NLGN2["NLGN2"]
    GLUD1 -->|"inhibits"| NLGN2
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"inhibits"| GLUD1
    MAP1LC3B["MAP1LC3B"]
    MAP1LC3B -->|"inhibits"| GLUD1
    GRID1["GRID1"]
    GRID1 -->|"interacts with"| GLUD1
    PRKCD -->|"inhibits"| GLUD1
    LAMP1 -->|"inhibits"| GLUD1
    CBLN1 -->|"interacts with"| GLUD1
    DISC1["DISC1"]
    DISC1 -->|"inhibits"| GLUD1
    ERBB4["ERBB4"]
    ERBB4 -->|"inhibits"| GLUD1
    GENES["GENES"]
    GENES -->|"inhibits"| GLUD1
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"therapeutic target"| GLUD1
    VDAC1["VDAC1"]
    VDAC1 -->|"therapeutic target"| GLUD1
    HSPA9["HSPA9"]
    HSPA9 -->|"therapeutic target"| GLUD1
    style GLUD1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (81)

TargetRelationTypeStr
Parkinson'S Diseaseassociated_withdisease0.70
Msinhibitsdisease0.65
Alsinhibitsdisease0.65
Anxietyinhibitsdisease0.65
Schizophreniainhibitsdisease0.65

Incoming (37)

SourceRelationTypeStr
SQSTM1inhibitsgene0.60
MAP1LC3Binhibitsgene0.60
GRID1interacts_withgene0.60
PRKCDinhibitsgene0.60
LAMP1inhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found