Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GLUD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GLUD1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, activates, therapeutic target. Associated with Als, Anxiety, Cancer. Connected to 60 entities in the SciDEX knowledge graph.
| Gene Symbol | GLUD1 |
| Full Name | Glutamate Dehydrogenase 1 |
| Aliases | Page for GLUD1 |
| Chromosome | 10q23.3 |
| Protein Type | Enzyme |
| Function | GLUD1 is a mitochondrial matrix enzyme belonging to the glutamate dehydrogenase family |
| Primary Expression | Liver, kidney, brain, pancreas |
| Amino Acids | 505 aa |
| Pathways | Glycolysis, Histone Modification, Mtor, Oxidative Phosphorylation, Oxidative Stress |
| UniProt ID | [P00341](https://www.uniprot.org/uniprot/P00341) |
| Ensembl ID | ENSG00000148671 |
| OMIM | 130120 |
| GeneCards | GLUD1 |
| Human Protein Atlas | GLUD1 |
| N-terminal antenna region | Contains the allosteric binding sites |
| Associated Diseases | Parkinson, Parkinson'S Disease |
| Interactions | LAMP1, PRKCD, CBLN1, BECN1, NRG1, NLGN2 |
| KG Connections | 118 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GLUD1["<b>GLUD1</b>"]
Ms{"Ms"}
GLUD1 -->|"inhibits"| Ms
Als{"Als"}
GLUD1 -->|"inhibits"| Als
Anxiety{"Anxiety"}
GLUD1 -->|"inhibits"| Anxiety
Schizophrenia{"Schizophrenia"}
GLUD1 -->|"inhibits"| Schizophrenia
Parkinson{"Parkinson"}
GLUD1 -->|"therapeutic target"| Parkinson
LAMP1["LAMP1"]
GLUD1 -->|"inhibits"| LAMP1
PRKCD["PRKCD"]
GLUD1 -->|"inhibits"| PRKCD
CBLN1["CBLN1"]
GLUD1 -->|"interacts with"| CBLN1
BECN1["BECN1"]
GLUD1 -->|"inhibits"| BECN1
Autophagy(["Autophagy"])
GLUD1 -->|"inhibits"| Autophagy
NRG1["NRG1"]
GLUD1 -->|"inhibits"| NRG1
NLGN2["NLGN2"]
GLUD1 -->|"inhibits"| NLGN2
SQSTM1["SQSTM1"]
SQSTM1 -->|"inhibits"| GLUD1
MAP1LC3B["MAP1LC3B"]
MAP1LC3B -->|"inhibits"| GLUD1
GRID1["GRID1"]
GRID1 -->|"interacts with"| GLUD1
PRKCD -->|"inhibits"| GLUD1
LAMP1 -->|"inhibits"| GLUD1
CBLN1 -->|"interacts with"| GLUD1
DISC1["DISC1"]
DISC1 -->|"inhibits"| GLUD1
ERBB4["ERBB4"]
ERBB4 -->|"inhibits"| GLUD1
GENES["GENES"]
GENES -->|"inhibits"| GLUD1
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"therapeutic target"| GLUD1
VDAC1["VDAC1"]
VDAC1 -->|"therapeutic target"| GLUD1
HSPA9["HSPA9"]
HSPA9 -->|"therapeutic target"| GLUD1
style GLUD1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson'S Disease | associated_with | disease | 0.70 |
| Ms | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Anxiety | inhibits | disease | 0.65 |
| Schizophrenia | inhibits | disease | 0.65 |
| Parkinson | therapeutic_target | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Glioblastoma | activates | disease | 0.65 |
| Parkinson | activates | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Schizophrenia | expressed_in | disease | 0.65 |
| LAMP1 | inhibits | gene | 0.60 |
| PRKCD | inhibits | gene | 0.60 |
| CBLN1 | interacts_with | gene | 0.60 |
| BECN1 | inhibits | gene | 0.60 |
| NRG1 | inhibits | gene | 0.60 |
| NLGN2 | inhibits | gene | 0.60 |
| SNCA | therapeutic_target | gene | 0.60 |
| LRPPRC | associated_with | gene | 0.60 |
| NDUFS2 | associated_with | gene | 0.60 |
| NDUFS1 | associated_with | gene | 0.60 |
| SDHA | therapeutic_target | gene | 0.60 |
| ERBB4 | inhibits | gene | 0.60 |
| DISC1 | inhibits | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| VDAC1 | therapeutic_target | gene | 0.60 |
| CYCS | therapeutic_target | gene | 0.60 |
| NDUFS1 | causes | gene | 0.60 |
| NDUFS2 | causes | gene | 0.60 |
| LRPPRC | causes | gene | 0.60 |
| ACO2 | activates | gene | 0.60 |
| HSPA9 | activates | gene | 0.60 |
| SNCA | activates | gene | 0.60 |
| SDHA | activates | gene | 0.60 |
| VDAC1 | activates | gene | 0.60 |
| CYCS | activates | gene | 0.60 |
| HSPA9 | therapeutic_target | gene | 0.60 |
| ACO2 | therapeutic_target | gene | 0.60 |
| GRID2 | transports | gene | 0.60 |
| GLUD2 | transports | gene | 0.60 |
| GRID1 | interacts_with | gene | 0.60 |
| CBLN2 | interacts_with | gene | 0.60 |
| Rb | interacts_with | protein | 0.60 |
| Autophagy | inhibits | pathway | 0.60 |
| OXIDATIVE STRESS | therapeutic_target | gene | 0.60 |
| Oxidative Phosphorylation | therapeutic_target | pathway | 0.60 |
| Oxidative Stress | therapeutic_target | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SQSTM1 | inhibits | gene | 0.60 |
| MAP1LC3B | inhibits | gene | 0.60 |
| GRID1 | interacts_with | gene | 0.60 |
| PRKCD | inhibits | gene | 0.60 |
| LAMP1 | inhibits | gene | 0.60 |
| CBLN1 | interacts_with | gene | 0.60 |
| DISC1 | inhibits | gene | 0.60 |
| ERBB4 | inhibits | gene | 0.60 |
| VDAC1 | therapeutic_target | gene | 0.60 |
| HSPA9 | therapeutic_target | gene | 0.60 |
| CYCS | therapeutic_target | gene | 0.60 |
| ACO2 | therapeutic_target | gene | 0.60 |
| BECN1 | inhibits | gene | 0.60 |
| NRG1 | inhibits | gene | 0.60 |
| HK2 | activates | gene | 0.60 |
| PDPK1 | activates | gene | 0.60 |
| KDM6A | regulates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| EGFR | regulates | gene | 0.60 |
| GBM | activates | gene | 0.60 |
| SNCA | therapeutic_target | gene | 0.60 |
| NDUFS1 | causes | gene | 0.60 |
| LRPPRC | causes | gene | 0.60 |
| SDHA | therapeutic_target | gene | 0.60 |
| NDUFS2 | causes | gene | 0.60 |
| ARRB2 | associated_with | gene | 0.60 |
| ATP1A3 | associated_with | gene | 0.60 |
| GENES | inhibits | gene | 0.60 |
| PARKINSON'S DISEASE | therapeutic_target | gene | 0.60 |
| IMMUNE INFILTRATION | therapeutic_target | gene | 0.60 |
| OXIDATIVE STRESS | therapeutic_target | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| ATP | therapeutic_target | gene | 0.60 |
| ROS | therapeutic_target | gene | 0.60 |
| AND | causes | gene | 0.60 |
| CYCS | co_expressed_with | gene | 0.50 |
| ATP | co_expressed_with | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||