Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GRID1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GRID1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, interacts with, implicated in. Associated with Ms. Connected to 16 entities in the SciDEX knowledge graph.
| Gene Symbol | GRID1 |
| Full Name | Glutamate Ionotropic Receptor Delta Type Subunit 1 |
| Protein Type | Receptor |
| Function | GRID1 (Glutamate Receptor Ionotropic Delta 1), also known as GluRδ1, is a member of the ionotropic glutamate receptor family. |
| Primary Expression | Prefrontal Cortex, Cortex, Ventral Tegmental Area, Substantia Nigra |
| Pathways | Autophagy |
| Ensembl ID | ENSG00000148677 |
| GeneCards | GRID1 |
| Human Protein Atlas | GRID1 |
| Ligand-binding domain (LBD) | Contains the glutamate binding site (though ligand gating is non-functional) |
| Three transmembrane domains | Form the ion channel pore |
| Intracellular C-terminal tail | Contains phosphorylation sites and PDZ-binding motifs |
| Associated Diseases | neurodegeneration |
| Interactions | GLUD1, LAMP1, PRKCD, CBLN1, BECN1, MAP1LC3B |
| KG Connections | 36 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GRID1["<b>GRID1</b>"]
Ms{"Ms"}
GRID1 -->|"inhibits"| Ms
GLUD1["GLUD1"]
GRID1 -->|"interacts with"| GLUD1
LAMP1["LAMP1"]
GRID1 -->|"inhibits"| LAMP1
PRKCD["PRKCD"]
GRID1 -->|"inhibits"| PRKCD
CBLN1["CBLN1"]
GRID1 -->|"inhibits"| CBLN1
BECN1["BECN1"]
GRID1 -->|"inhibits"| BECN1
Autophagy(["Autophagy"])
GRID1 -->|"inhibits"| Autophagy
MAP1LC3B["MAP1LC3B"]
GRID1 -->|"inhibits"| MAP1LC3B
SQSTM1["SQSTM1"]
GRID1 -->|"inhibits"| SQSTM1
AND["AND"]
GRID1 -->|"inhibits"| AND
AUTOPHAGY["AUTOPHAGY"]
GRID1 -->|"inhibits"| AUTOPHAGY
neurodegeneration["neurodegeneration"]
GRID1 -->|"implicated in"| neurodegeneration
SQSTM1 -->|"inhibits"| GRID1
MAP1LC3B -->|"inhibits"| GRID1
CBLN1 -->|"inhibits"| GRID1
LAMP1 -->|"inhibits"| GRID1
BECN1 -->|"inhibits"| GRID1
style GRID1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | inhibits | disease | 0.65 |
| Schizophrenia | expressed_in | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| GLUD1 | interacts_with | gene | 0.60 |
| LAMP1 | inhibits | gene | 0.60 |
| PRKCD | inhibits | gene | 0.60 |
| CBLN1 | inhibits | gene | 0.60 |
| BECN1 | inhibits | gene | 0.60 |
| MAP1LC3B | inhibits | gene | 0.60 |
| SQSTM1 | inhibits | gene | 0.60 |
| SLC17A7 | expressed_in | gene | 0.60 |
| GRIN2B | expressed_in | gene | 0.60 |
| CBLN2 | interacts_with | gene | 0.60 |
| Rb | interacts_with | protein | 0.60 |
| Autophagy | inhibits | pathway | 0.60 |
| AUTOPHAGY | inhibits | gene | 0.60 |
| Dopaminergic | activates | cell_type | 0.60 |
| AND | expressed_in | gene | 0.60 |
| Albumin | activates | protein | 0.60 |
| Ventral Tegmental Area | expressed_in | brain_region | 0.55 |
| Prefrontal Cortex | expressed_in | brain_region | 0.55 |
| Cortex | expressed_in | brain_region | 0.55 |
| Substantia Nigra | expressed_in | brain_region | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SQSTM1 | inhibits | gene | 0.60 |
| MAP1LC3B | inhibits | gene | 0.60 |
| CBLN1 | inhibits | gene | 0.60 |
| LAMP1 | inhibits | gene | 0.60 |
| BECN1 | inhibits | gene | 0.60 |
| GRIN2B | expressed_in | gene | 0.60 |
| GLUD1 | interacts_with | gene | 0.60 |
| GRID2 | expressed_in | gene | 0.60 |
| GLUD2 | transports | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| SYNAPSE | interacts_with | gene | 0.60 |
| SLC17A7 | expressed_in | protein | 0.50 |
| SCHIZOPHRENIA | expressed_in | disease | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||