gene

GRID1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRID1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections
0Hypotheses
0Analyses
23Outgoing
13Incoming
0Experiments

Summary

GRID1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, interacts with, implicated in. Associated with Ms. Connected to 16 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolGRID1
Full NameGlutamate Ionotropic Receptor Delta Type Subunit 1
Protein TypeReceptor
FunctionGRID1 (Glutamate Receptor Ionotropic Delta 1), also known as GluRδ1, is a member of the ionotropic glutamate receptor family.
Primary ExpressionPrefrontal Cortex, Cortex, Ventral Tegmental Area, Substantia Nigra
PathwaysAutophagy
Ensembl IDENSG00000148677
GeneCardsGRID1
Human Protein AtlasGRID1
Ligand-binding domain (LBD)Contains the glutamate binding site (though ligand gating is non-functional)
Three transmembrane domainsForm the ion channel pore
Intracellular C-terminal tailContains phosphorylation sites and PDZ-binding motifs
Associated Diseasesneurodegeneration
InteractionsGLUD1, LAMP1, PRKCD, CBLN1, BECN1, MAP1LC3B
KG Connections36 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

GRID1 — Glutamate Ionotropic Receptor Delta Type Subunit 1

gene · 2567 words

GRID2 — Glutamate Ionotropic Receptor Delta Type Subunit 2

gene · 1942 words

CBLN1 Gene

gene · 1688 words

GLUD2 Gene

gene · 1253 words

GluRδ1 (GRID1) Protein

protein · 1020 words

GRID2 Protein

protein · 652 words

Pathway Diagram

graph TD
    GRID1["<b>GRID1</b>"]
    Ms{"Ms"}
    GRID1 -->|"inhibits"| Ms
    GLUD1["GLUD1"]
    GRID1 -->|"interacts with"| GLUD1
    LAMP1["LAMP1"]
    GRID1 -->|"inhibits"| LAMP1
    PRKCD["PRKCD"]
    GRID1 -->|"inhibits"| PRKCD
    CBLN1["CBLN1"]
    GRID1 -->|"inhibits"| CBLN1
    BECN1["BECN1"]
    GRID1 -->|"inhibits"| BECN1
    Autophagy(["Autophagy"])
    GRID1 -->|"inhibits"| Autophagy
    MAP1LC3B["MAP1LC3B"]
    GRID1 -->|"inhibits"| MAP1LC3B
    SQSTM1["SQSTM1"]
    GRID1 -->|"inhibits"| SQSTM1
    AND["AND"]
    GRID1 -->|"inhibits"| AND
    AUTOPHAGY["AUTOPHAGY"]
    GRID1 -->|"inhibits"| AUTOPHAGY
    neurodegeneration["neurodegeneration"]
    GRID1 -->|"implicated in"| neurodegeneration
    SQSTM1 -->|"inhibits"| GRID1
    MAP1LC3B -->|"inhibits"| GRID1
    CBLN1 -->|"inhibits"| GRID1
    LAMP1 -->|"inhibits"| GRID1
    BECN1 -->|"inhibits"| GRID1
    style GRID1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (23)

TargetRelationTypeStr
Msinhibitsdisease0.65
Schizophreniaexpressed_indisease0.65
Alsexpressed_indisease0.65
GLUD1interacts_withgene0.60
LAMP1inhibitsgene0.60

Incoming (13)

SourceRelationTypeStr
SQSTM1inhibitsgene0.60
MAP1LC3Binhibitsgene0.60
CBLN1inhibitsgene0.60
LAMP1inhibitsgene0.60
BECN1inhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found