| Gene Symbol | DRD3PROTEIN |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | the limbic system, making it a key player in reward processing, emotional regulation, and motivational behavior |
| Subcellular Localization | ** | Plasma membrane, dendrites, synapses | |
| Molecular Weight | 130 kDa |
| GeneCards | DRD3PROTEIN |
| Human Protein Atlas | DRD3PROTEIN |
| N-terminal extracellular domain | Contains glycosylation sites for proper folding and trafficking |
| Transmembrane domains (TM1-TM7) | Seven alpha-helices that span the plasma membrane |
| Three extracellular loops (ECL1-ECL3) | Involved in ligand binding, particularly dopamine and therapeutic compounds |
| Three intracellular loops (ICL1-ICL3) | Couple to G proteins for signal transduction |
| C-terminal intracellular tail | Contains serine/threonine residues for phosphorylation and desensitization |
| Inhibition of adenylate cyclase | Couples to Gi/o proteins, reducing cAMP production |
| Modulation of ion channels | Activates inward-rectifier potassium channels (GIRKs), hyperpolarizing neurons |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | D-520 |
| Interactions | AMPK, DRD2, ULK1 |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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