gene

DRD2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DRD2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

809Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

DRD2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with ALS, Als, Cardiac. Connected to 173 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	DRD2
Full Name	Dopamine Receptor D2
Chromosome	11q23.2
Protein Type	Gpcr
Target Class	Gpcr
Function	is an important component in the neurobiology of neurodegenerative diseases.
Mechanism of Action	Small molecule agonist or antagonist modulating dopamine signaling
Primary Expression	Striatum, Substantia nigra, Pituitary, Cortex
Druggability	High (0.90)
Clinical Stage	Approved
Pathways	PI3K
UniProt ID	P14416
NCBI Gene ID	1819
Ensembl ID	ENSG00000149295
GeneCards	DRD2
Human Protein Atlas	DRD2
Associated Diseases	ALS, Addiction, Alzheimer, Autism, Bipolar
Known Drugs/Compounds	L-DOPA, levodopa, D-520, quinpirole, UNC9995
Interactions	SNCA, JUN, HRH3, HCRTR2, ADRA1B, DRD1
SciDEX Target	View Target Profile (6 clinical trials)
KG Connections	809 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure: DRD2 — PDB 6CM4 Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DRD2["DRD2"] -->|"associated"| neurodegeneration["neurodegeneration"]
    DRD2["DRD2"] -->|"interacts"| SNCA["SNCA"]
    DRD2["DRD2"] -->|"co discussed"| CHR2["CHR2"]
    DRD2["DRD2"] -->|"co discussed"| CLOCK["CLOCK"]
    DRD2["DRD2"] -->|"co discussed"| CRH["CRH"]
    DRD2["DRD2"] -->|"co discussed"| BDNF["BDNF"]
    SNCA_1["SNCA"] -->|"interacts"| DRD2["DRD2"]
    FOXP3["FOXP3"] -->|"co discussed"| DRD2["DRD2"]
    TNFA["TNFA"] -->|"co discussed"| DRD2["DRD2"]
    PPARGC1A["PPARGC1A"] -->|"co discussed"| DRD2["DRD2"]
    style DRD2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (539)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
Dyskinesia	associated_with	phenotype	0.90
GI/O signaling	activates	pathway	0.90
dyskinesia	biomarker_for	phenotype	0.90
locomotor suppression	mediates	phenotype	0.90
Motor Fluctuations	associated_with	phenotype	0.90
levodopa adverse drug reactions	mediates	phenotype	0.85
p11	binds	protein	0.80
β-arrestin2	interacts_with	protein	0.80
NLRP3	interacts_with	gene	0.80
dopamine receptor	regulates	receptor	0.80
Depression	implicated_in	disease	0.80
ACOD1	regulates	gene	0.80
astrocytes	expressed_in	cell_type	0.80
basal_ganglia_circuit	modulates	pathway	0.80
Motor fluctuations	risk_factor_for	phenotype	0.75
Als	therapeutic_target	disease	0.75
M1 Macrophages	associated_with	cell_type	0.70
NF-κB Signaling	inhibits	pathway	0.70
Parkinson Disease	associated_with	disease	0.70
Glutamatergic Transmission	regulates	biological_process	0.70
Astrocyte Inflammatory Injury	associated_with	biological_process	0.70
MYD88	associated_with	protein	0.70
Chronic Sleep Deprivation	contributes_to	biological_process	0.70
schizophrenia	interacts_with	disease	0.70
dopamine receptor	interacts_with	receptor	0.70
dopamine receptor	activates	receptor	0.70
dopamine receptor	inhibits	receptor	0.70
dopamine receptor	transported_by	receptor	0.70
Complement	therapeutic_target	pathway	0.70
Sepsis	implicated_in	disease	0.70
oxidative stress response	participates_in	pathway	0.70
Parkinson'S Disease	risk_factor_for	disease	0.70
DOPAMINE	causes	phenotype	0.70
Opioid	associated_with	disease	0.65
Addiction	associated_with	disease	0.65
L-DOPA	treats	drug	0.65
TH	produces	gene	0.65
Ms	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Als	activates	disease	0.65
Parkinson	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	activates	disease	0.65
Als	protects_against	disease	0.65
Parkinson	protects_against	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
ALS	associated_with	disease	0.65

Incoming (270)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
Spnphilin	interacts_with	protein	0.95
quinpirole	targets	drug	0.95
RGS6	modulates	protein	0.90
D-520	binds	drug	0.90
Spnphilin	promotes	protein	0.90
h-072b2f5d	targets_gene	hypothesis	0.90
Spnphilin	therapeutic_target	protein	0.85
h-072b2f5d	targets	hypothesis	0.80
levodopa	targets	drug	0.80
ANKK1	interacts_with	gene	0.80
COMT	interacts_with	gene	0.80
UNC9995	activates	compound	0.80
L-DOPA	protects_against	drug	0.70
ALPHA-SYNUCLEIN	interacts_with	protein	0.70
DRD1	contributes_to	gene	0.65
ALPHA-SYNUCLEIN	associated_with	concept	0.65
NEURONS	produces	cell_type	0.65
NEUROINFLAMMATION	regulates	phenotype	0.65
LRRK2	associated_with	gene	0.60
GCH1	associated_with	gene	0.60
JUN	activates	gene	0.60
GPNMB	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
CAMK2A	associated_with	gene	0.60
COMT	associated_with	gene	0.60
FYN	associated_with	gene	0.60
HOMER1	associated_with	gene	0.60
SRC	associated_with	gene	0.60
UBC	associated_with	gene	0.60
FOXP2	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
CHRNA5	associated_with	gene	0.60
DRD4	associated_with	gene	0.60
OVERVIEW	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
APOE	co_discussed	gene	0.60
PENK	expressed_in	gene	0.60
NCAM1	expressed_in	gene	0.60
DNMT1	expressed_in	gene	0.60
AKT1	expressed_in	gene	0.60
COMT	expressed_in	gene	0.60
DLGAP2	expressed_in	gene	0.60
STAT3	expressed_in	gene	0.60
ARG1	expressed_in	gene	0.60
KCNH2	therapeutic_target	gene	0.60
IDH1	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.605

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DRD2

Understanding Entity Pages

Summary

Wiki Pages (21)

DRD2 Gene

Dorsal Attention Network

reward-circuit

rgs9

Mesolimbic Dopamine Pathway

Dopamine Signaling Pathway

Biomarkers of Alzheimer Disease

Biomarker-Therapeutic Development Nexus

medium-spiny-neurons-huntington-disease

Biomarkers in Neurodegeneration

Serotonergic Dysfunction in Neurodegeneration

Biomarkers for Parkinson's Disease

GRIN1 — NMDA Receptor Subunit 1

ADCY3 — Adenylate Cyclase 3

CRISPR Gene Editing for Parkinson's Disease

SNCA — Alpha-Synuclein

Biomarkers for Corticobasal Degeneration

Sirtuin Modulators for Parkinson's Disease

Huntington's Disease Medium Spiny Neurons

Biomarkers for Progressive Supranuclear Palsy