protein 713 words KG: DYNAMIN1 2026-03-20
kind:proteinsection:proteinsstate:published
Contents

Dynamin-1 Protein (DNM1)

🔬 Protein Info
Gene SymbolDYNAMIN1
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionneurons, where it mediates the final scission of synaptic vesicles from the plasma membrane
Molecular Weight100 kDa
GeneCardsDYNAMIN1
Human Protein AtlasDYNAMIN1
TargetApproach
Dynamin-1 activitySmall molecule enhancers
Endocytic pathwayModulators of clathrin-mediated endocytosis
Synaptic vesicle poolsRestoration of vesicle recycling
Associated Diseasesneurodegeneration
KG Connections4 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41

Related Analyses (8)

Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (5)

TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: associated_with
Oligodendrocytes
redirect · KG edge: associated_with
Neurons
entity · KG edge: associated_with
Microglia in Neurodegeneration
entity · KG edge: expressed_in
Neurodegeneration
disease · KG edge: contributes_to

Knowledge Graph (4 edges)

DYNAMIN1 associated_with TREM2
DYNAMIN1 expressed_in microglia
DYNAMIN1 associated_with neurons
DYNAMIN1 associated_with oligodendrocytes