protein 1,323 words KG: FE65PROTEIN 2026-03-27
kind:proteinsection:proteinsstate:published
Contents

FE65 Protein

🔬 Protein Info
Gene SymbolFE65
AliasesFE65, APBB1, RIR
Protein FamilyAPP binding family (APBB)
FunctionFE65 contains multiple protein-protein interaction domains including a WW domain and two phosphotyrosine-binding (PTB) domains, allowing it to function as a molecular scaffold linking APP to divers...
Subcellular LocalizationSignals (NLS)**: FE65 can translocate to the nucleus where it functions as a tra
Molecular Weight60 kDa
Amino Acids580 aa
Pathwaysoxidative stress response, cholesterol homeostasis, blood-brain barrier
UniProt IDQ9BQZ5
GeneCardsFE65
Human Protein AtlasFE65
GeneAPBB1
PDBAvailable (multiple structures)
Mol. Weight60 kDa (580 amino acids)
InteractionsAPP
KG Connections6 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (21)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
LRP1-Dependent Tau Uptake Disruption
Score: 0.44
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in