protein 1,244 words KG: IDO1PROTEIN
Contents

IDO1 Protein

🔬 Protein Info
Gene SymbolIDO1
Full NameIndoleamine 2,3-Dioxygenase 1
Chromosome8p11.21
Functionis a gene on chromosome 8p11.
Primary ExpressionMicroglia, astrocytes, macrophages, dendritic cells
Molecular Weight45 kDa
Amino Acids403 aa
Exons10
PathwaysGlycolysis, blood-brain barrier, ferroptosis, oxidative stress response, synaptic plasticity
UniProt IDP14902
NCBI Gene ID3620
Ensembl IDENSG00000131203
OMIM147435
GeneCardsIDO1
Human Protein AtlasIDO1
Associated Diseasescancer, Infection, neuroinflammation
InteractionsAHR, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, ASTROCYTE
KG Connections91 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (4)

Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.60
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.67
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (7)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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