disease

cancer

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about cancer: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15770Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

cancer is a disease characterized by neurodegeneration research. Key relationships include: implicated in, associated with, regulates. Connected to 84 entities in the SciDEX knowledge graph.

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Disease Info

Questionnaires	Medical history, lifestyle, diet, cognitive function[@elliott2019]
Physical Measures	Anthropometry, blood pressure, grip strength[@miller2016]
Biological Samples	Blood, urine, saliva for genetic and biomarker analysis[@fry2017]
MRI	Structural brain imaging[@alfaroalmagro2018]
fMRI	Functional connectivity mapping[@miller2019]
Diffusion MRI	White matter tractography[@tournier2019]
Electronic Health Records	Hospital admissions, primary care, death records[@biobank2024]
Cancer Registries	Cancer incidence data[@biobank2024a], [@biobank2024b]
Associated Genes	HSPC1, type_I_IFN, MTOR, BECN1, JUN, TREM2, PI3K, SLC16A2
Therapeutic Agents	autophagy modulators, small-molecule kinase modulators, venetoclax, RAS inhibitors, PRMT inhibitors, LYTAC
KG Connections	1422 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

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Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

mechanism · 7227 words

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NPM1 Gene

gene · 5653 words

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Pathway Diagram

graph TD
    PTEN_loss["PTEN loss"] -->|"causes"| cancer["cancer"]
    Wnt_pathway["Wnt pathway"] -->|"causes"| cancer["cancer"]
    JUN["JUN"] -->|"causes"| cancer["cancer"]
    MCOLN1["MCOLN1"] -->|"treats"| cancer["cancer"]
    style cancer fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (6415)

Target	Relation	Type	Str
HSPG2	regulates	concept	0.50
PRMT1	causes	concept	0.50
PRMT1	inhibits	concept	0.50
PRMT1	activates	concept	0.50
PRMT1	expressed_in	concept	0.50
PRMT1	regulates	concept	0.50
ferroptosis	activates	phenotype	0.50
ALOX12	associated_with	concept	0.50
ALOX12	activates	concept	0.50
ferroptosis	regulates	phenotype	0.50
ferroptosis	associated_with	phenotype	0.50
ferroptosis	inhibits	phenotype	0.50
LOXL1-4	regulates	concept	0.50
OCT4	activates	concept	0.50
ferroptosis	interacts_with	phenotype	0.50
ST6GAL1	expressed_in	concept	0.50
ST3GAL2	expressed_in	concept	0.50
SRPK1	associated_with	concept	0.50
SRPK1	regulates	concept	0.50
SRPK1	expressed_in	concept	0.50
Liver Cancer	associated_with	disease	0.50
Chemoresistance	activates	pathway	0.50
disease	interacts_with	disease	0.50
DIABETES	associated_with	disease	0.50
Heart Failure	associated_with	disease	0.50
disease	associated_with	disease	0.50
Prostate Cancer	regulates	disease	0.50
EXTRACELLULAR MATRIX	regulates	concept	0.50
TUMOR	associated_with	disease	0.50
Epithelial-Mesenchymal Transition	associated_with	process	0.50
Epithelial Cell	interacts_with	cell_type	0.50
apoptosis	associated_with	process	0.50
STEM CELLS	associated_with	concept	0.50
BREAST CANCER	associated_with	disease	0.50
NEURODEGENERATIVE DISEASE	associated_with	concept	0.50
apoptosis	regulates	process	0.50
Ovarian Cancer	inhibits	disease	0.50
Chemoresistance	associated_with	pathway	0.50
HOMOLOGOUS RECOMBINATION	inhibits	concept	0.50
Cardiovascular	regulates	disease	0.50
Drug Resistance	associated_with	pathway	0.50
Drug Resistance	causes	pathway	0.50
Drug Resistance	inhibits	pathway	0.50
TUMOR	activates	disease	0.50
Stem Cell	activates	cell_type	0.50
DNA DAMAGE	activates	concept	0.50
Tumor Microenvironment	activates	process	0.50
Epithelial-Mesenchymal Transition	activates	process	0.50
PHGDH	causes	concept	0.50
BREAST CANCER	causes	disease	0.50

Incoming (9355)

Source	Relation	Type	Str
STAT3	therapeutic_target	protein	0.95
TP53	risk_factor_for	gene	0.95
BCL2	therapeutic_target	protein	0.95
MYC	associated_with	gene	0.95
NRAS	risk_factor_for	gene	0.95
HRAS	risk_factor_for	gene	0.95
HRAS	causes	gene	0.95
TP53	suppresses	gene	0.95
P53	associated_with	protein	0.95
KRAS	risk_factor_for	gene	0.95
KRAS	causes	gene	0.95
RAS	therapeutic_target	gene	0.95
TP53	regulates	gene	0.93
IGF1R	therapeutic_target	protein	0.92
p53	therapeutic_target	protein	0.92
mutant TP53	risk_factor_for	gene	0.92
BCL-2 inhibitors	therapeutic_target	drug	0.92
RAS inhibitors	treats	drug	0.92
P53	protects_against	gene	0.92
PTEN loss	causes	phenotype	0.90
MDM2	associated_with	protein	0.90
MDM2 inhibitors	therapeutic_target	drug	0.90
mutant P53	risk_factor_for	gene	0.90
venetoclax	treats	drug	0.90
TP53	therapeutic_target	gene	0.90
EGFR	associated_with	protein	0.90
RAS/RAF/MAP kinase pathway	associated_with	pathway	0.90
mutant IDH1	drives	protein	0.90
mutant IDH2	drives	protein	0.90
CGAS	drives	protein	0.90
IL-6	therapeutic_target	protein	0.90
P53	therapeutic_target	gene	0.90
HER2	therapeutic_target	protein	0.90
senescence	associated_with	process	0.90
STING	therapeutic_target	protein	0.89
PI3K	therapeutic_target	protein	0.88
senescence	prevents	process	0.87
ubiquitin ligases	therapeutic_target	protein	0.85
deubiquitinases	therapeutic_target	protein	0.85
MDM2 degradation	prevents	process	0.85
NAD+ metabolism	drives	pathway	0.85
ALOX12	risk_factor_for	gene	0.85
IGF2R	associated_with	protein	0.85
cuproptosis	therapeutic_target	process	0.85
MTORC1	promotes	protein	0.85
IL-6	risk_factor_for	protein	0.85
RAF	associated_with	protein	0.85
TNF signaling	therapeutic_target	pathway	0.83
TRPM	biomarker_for	protein	0.82
Wnt pathway	causes	pathway	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do oligodendrocytes require DNA repair enhancement or inhibition for neuroprotec

neurodegeneration | 2026-04-11 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

cancer

Understanding Entity Pages

Summary

Wiki Pages (21)

UK Biobank

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

NPM1 Gene

NRF2 Oxidative Stress Pathway

Alzheimer's Disease

Frontotemporal Dementia (FTD)

TREM2 Mechanism Hub

Mitochondrial Quality Control

GSK-3β in Neurodegeneration

HNRNPA2B1 Protein

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Autophagy Mechanisms

oxidative-stress-comparison

amyloid-beta-metalloproteinases

University of Heidelberg

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

Sulforaphane and Nrf2 Activation for Neuroprotection