protein 637 words KG: LRP3
Contents

LRP3 Protein

🔬 Protein Info
Gene SymbolLRP3
Full NameLow Density Lipoprotein Receptor-Related Protein 3
Chromosome19q13.31
Protein FamilyLDLR receptor family
Protein TypeReceptor
FunctionLRP-family proteins typically combine extracellular ligand-binding domains with transmembrane and cytoplasmic motifs that support ligand uptake, trafficking, and downstream signaling.[@herz2001] Withi
Primary ExpressionBrain (cortex, hippocampus), heart, skeletal muscle
Molecular Weight250 kDa
Amino Acids325 aa
UniProt IDO75074
NCBI Gene ID4037
Ensembl IDENSG00000186603
GeneCardsLRP3
Human Protein AtlasLRP3
Transmembrane domainSingle pass membrane-spanning region
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

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UniProtWikipedia

Related Hypotheses (43)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
SASP-Mediated Complement Cascade Amplification
Score: 0.82
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.80
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.78
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Multi-Modal Stress Response Harmonization
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Senescent Cell Mitochondrial DNA Release
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
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Related Analyses (20)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (2)

Molecular characterization of RBG-NLRP3 binding interaction
exploratory · proposed · Score: 0.90
NLRP3 Inflammasome Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Exosomal miR-155 in Neurodegeneration
biomarker · Pages share 3 hypotheses
Synaptic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses
Liquid Biopsy in Neurodegeneration
biomarker · Pages share 3 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

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