protein 637 words KG: LRP3 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

LRP3 Protein

🔬 Protein Info
Gene SymbolLRP3
Full NameLow Density Lipoprotein Receptor-Related Protein 3
Chromosome19q13.31
Protein FamilyLDLR receptor family
Protein TypeReceptor
FunctionLRP-family proteins typically combine extracellular ligand-binding domains with transmembrane and cytoplasmic motifs that support ligand uptake, trafficking, and downstream signaling.[@herz2001] Withi
Primary ExpressionBrain (cortex, hippocampus), heart, skeletal muscle
Molecular Weight~250 kDa
Amino Acids325 aa
UniProt IDO75174
NCBI Gene ID4037
Ensembl IDENSG00000141548
GeneCardsLRP3
Human Protein AtlasLRP3
Protein NameLow-Density Lipoprotein Receptor-Related Protein 3
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
SASP-Mediated Complement Cascade Amplification
Score: 0.70
TREM2-Dependent Microglial Senescence Transition
Score: 0.69

Related Analyses (21)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (2)

Molecular characterization of RBG-NLRP3 binding interaction
exploratory · proposed · Score: 0.90
NLRP3 Inflammasome Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses
WNK1 Kinase in Neurodegeneration
mechanism · Pages share 3 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 3 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 3 hypotheses