protein 785 words KG: LRP8APOER2PROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

LRP8 (ApoER2) Protein

🔬 Protein Info
Gene SymbolLRP8APOER2
AliasesLRP8APOER2PROTEIN
Protein FamilyLDL receptor family (LDLR)
FunctionLRP8 (also known as ApoER2 or apolipoprotein E receptor 2) is a member of the LDL receptor family that plays crucial roles in synaptic function, Reelin signaling, and neuronal migration.
Subcellular LocalizationPlasma membrane, Postsynaptic density, Synapses
UniProt IDQ9Y6X0
GeneCardsLRP8APOER2
Human Protein AtlasLRP8APOER2
GeneLRP8
PDB1JYH, 1OXM
Mol. Weight~110 kDa
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (14)

Cholesterol-CRISPR Convergence Therapy for Neurodegeneration
Score: 0.48
APOE Isoform Expression Across Glial Subtypes
Score: 0.48
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54

Related Analyses (10)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (7)

AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Posi
clinical · proposed · Score: 0.40
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau
clinical · proposed · Score: 0.40
Biomarker-Guided Sequential Therapy Selection in Alzheimer's
clinical · proposed · Score: 0.40
Blood-Based Biomarker Panel for Early AD Detection
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

ALA-enriched Nutrition for APOE4 Carriers with MCI (NCT
clinical · Pages share 9 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 9 hypotheses
LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 9 hypotheses
APOE4 (Apolipoprotein E4)
disease · Pages share 8 hypotheses
APOE3 (Apolipoprotein E3)
disease · Pages share 8 hypotheses