| Gene Symbol | MAPK8 (JNK1), MAPK9 (JNK2), MAPK10 (JNK3) |
| Aliases | JNK |
| Chromosome | MAPK8: 10q11.22, MAPK9: 5q35.1, MAPK10: 4q21.3 |
| Protein Type | Kinase |
| Function | Upstream activation: Stress signals (UV radiation, oxidative stress, inflammatory cytokines) activate MAPKKKs such as MEKK1, MLK3, and TAK1 |
| Molecular Weight | ~46-48 kDa per isoform |
| Pathways | Akt, Apoptosis, Autophagy, Differentiation, Ferroptosis |
| UniProt IDs | P45983 (JNK1), P45984 (JNK2), P53779 (JNK3) |
| Compound | Selectivity |
| SP600125 | Broad JNK inhibitor |
| JNK-IN-8 | Selective JNK inhibitor |
| CC-401 (CC-930) | JNK inhibitor |
| D-JNKI1 | Peptide inhibitor |
| MKK4 | Phosphorylation |
| MKK7 | Phosphorylation |
| Associated Diseases | AD, ALI, ALS, AMI, Aging |
| Known Drugs/Compounds | N-ACETYLCYSTEINE, RAPAMYCIN, NAC, Palmitic Acid, Quercetin, SP600125 |
| Interactions | RIPK3, G3BP1, FAM134B, BCL2, PEX3, P62 |
| KG Connections | 2173 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |