protein 1,561 words KG: P60484
Contents

PTEN Protein (Phosphatase and Tensin Homolog)

🔬 Protein Info
Gene SymbolP60484
Protein TypePhosphatase
Functionis a dual-specificity phosphatase that functions as a major negative regulator of the phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway.
Subcellular Localization| Cytoplasm, nucleus, plasma membrane
Molecular Weight47 kDa
Amino Acids403 aa
GeneCardsP60484
Human Protein AtlasP60484
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (9)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
APOE-Dependent Autophagy Restoration
Score: 0.89
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (7)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (1)

Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40

Key Papers (1)

Assessment of the Spatial Distribution of Moisture Content in Granular
Sensors (Basel, Switzerland) 2024

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Beta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 4 hypotheses
IL-6 (Interleukin-6) in Neurodegeneration
biomarker · Pages share 4 hypotheses
BEACoN Study - Biomarker Exploration in Aging, Cognitio
clinical · Pages share 4 hypotheses
Olfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 4 hypotheses

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