| Gene Symbol | SLC2A4RG |
| Aliases | SLC2A4RGPROTEIN |
| Chromosome | 20q13.33 |
| Function | The protein belongs to the Mondo family of basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factors, sharing structural and functional homology with MLX (Max-like protein X) and MLXIP ... |
| Subcellular Localization | protein forms functional heterodimers with MLX (Max-like protein X), creating a |
| GeneCards | SLC2A4RG |
| Human Protein Atlas | SLC2A4RG |
| N-terminal regulatory domain | Contains transcriptional activation regions and protein-protein interaction motifs that recruit co-activators and chromatin remodelers |
| Basic Helix-Loop-Helix (bHLH) domain | Enables DNA binding to E-box consensus sequences (CANNTG) in target gene promoters |
| Leucine zipper (LZ) region | Facilitates dimerization with partner proteins, primarily MLX family members |
| C-terminal region | Contains additional regulatory sequences that modulate protein stability and nuclear localization |
| Insulin response elements | Mediate insulin-stimulated expression in insulin-responsive tissues |
| Glucose response elements | Activate transcription in response to glucose availability |
| Mitochondrial biogenesis genes | PGC-1α (PPARGC1A), NRF1, NRF2 |
| Glucose metabolism enzymes | Hexokinase, phosphofructokinase |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |