protein 1,308 words KG: VEGFR1PROTEIN 2026-03-29
kind:proteinsection:proteinstopic:alzheimerstopic:parkinsonsstate:published
Contents

VEGFR1 (FLT1) Protein

🔬 Protein Info
Gene SymbolFLT1
Full NameFms Related Receptor Tyrosine Kinase 1 (VEGF Receptor 1)
Chromosome13q12
Protein TypeReceptor
Functionencodes a cell surface receptor for VEGF family members that plays critical roles in angiogenesis, vascular development, hematopoiesis, and neuroprotection.
Molecular Weight180 kDa
Amino Acids338 aa
PathwaysPI3K, MAPK
UniProt IDP17948
NCBI Gene ID2321
Ensembl IDENSG00000102755
OMIM165040
GeneCardsFLT1
Human Protein AtlasFLT1
Structural FeatureDetails
Associated DiseasesAlzheimer's disease, Parkinson's disease
Known Drugs/Compoundsfruquintinib
KG Connections1 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (10)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48
Retinal Vascular Microcirculation Rescue
Score: 0.54

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 4 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 4 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 4 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 4 hypotheses