| Gene Symbol | ent-gene-adf72f43 |
| [APP](/entities/app-protein)/PS1 Mice | AhR agonists reduced amyloid-beta plaque burden and improved cognitive function in APP/PS1 transgenic mice [@ahr2022] |
| 3xTg-AD Mice | AhR activation decreased tau phosphorylation and neuroinflammation markers [@tau2023] |
| In vitro | AhR ligands protected against amyloid-beta-induced neurotoxicity in neuronal cultures [@neuroprotective2021] |
| MPTP Model | AhR agonists protected dopaminergic neurons from MPTP-induced toxicity [@ahr2022a] |
| 6-OHDA Model | AhR activation attenuated dopaminergic neuron loss [@protective2021] |
| SOD1 G93A Mice | AhR agonists delayed disease progression and extended survival in SOD1 ALS mouse model [@ahr2023] |
| NCT03730662 | Study of AhR modulator in Parkinson's disease psychosis - Completed [@clinical2022] |
| Common adverse effects | Mild gastrointestinal symptoms, headache, transient liver enzyme elevations |
| Serious concerns | Long-term AhR activation may have immunosuppressive effects; careful dosing required |
| Drug interactions | AhR inducers/inhibitors may affect metabolism of other drugs via CYP450 enzymes |
| Contraindications | Caution in patients with liver disease; not recommended during pregnancy |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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