| Gene Symbol | ent-gene-5b0668d7 |
| Approach | Mechanism |
| RAGE domain blockers | Bind extracellular domain, block ligand interaction |
| RAGE antagonists | Inhibit intracellular signaling |
| Anti-RAGE antibodies | Neutralize RAGE or its ligands |
| Decoy receptors | Soluble RAGE-Fc fusion proteins |
| HMGB1 antagonists | Block RAGE ligand activation |
| S100B neutralization | Block astrocyte-derived activation |
| Agent | Mechanism |
| Anti-HMGB1 antibodies | Neutralize HMGB1 alarmin |
| Box A peptide | HMGB1 antagonist |
| Glycyrrhizin | HMGB1 inhibitor |
| Biomarker | Source |
| sRAGE | Plasma, CSF |
| HMGB1 | CSF, plasma |
| RAGE expression | PET ligands (in development) |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |