Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VE-cadherin: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | VE |
| Full Name | cadherin |
| Pathways | Reelin Secretion, VE-cadherin Trafficking |
| GeneCards | VE |
| Human Protein Atlas | VE |
| Interactions | ARF6, Exocyst Complex |
| KG Connections | 13 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
VE_cadherin["VE-cadherin"] -->|"mediates"| Adherens_Junction_Remodeling["Adherens Junction Remodeling"]
style Adherens_Junction_Remodeling fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
VE_cadherin["VE-cadherin"] -->|"modulates"| Lymphatic_Permeability["Lymphatic Permeability"]
style Lymphatic_Permeability fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
VE_cadherin["VE-cadherin"] -->|"modulates"| Cytoskeletal_Remodeling["Cytoskeletal Remodeling"]
style Cytoskeletal_Remodeling fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
VE_cadherin["VE-cadherin"] -->|"regulates"| Reelin_Secretion["Reelin Secretion"]
style Reelin_Secretion fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
VE_cadherin["VE-cadherin"] -->|"interacts"| ARF6["ARF6"]
style ARF6 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
VE_cadherin["VE-cadherin"] -->|"interacts"| Exocyst_Complex["Exocyst Complex"]
style Exocyst_Complex fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
VE_cadherin["VE-cadherin"] -->|"involved in"| VE_cadherin_Trafficking["VE-cadherin Trafficking"]
style VE_cadherin_Trafficking fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
TMEM16F["TMEM16F"] -->|"regulates"| VE_cadherin["VE-cadherin"]
style TMEM16F fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
ARF6_1["ARF6"] -->|"interacts"| VE_cadherin["VE-cadherin"]
style ARF6_1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
Exocyst_Complex_2["Exocyst Complex"] -->|"interacts"| VE_cadherin["VE-cadherin"]
style Exocyst_Complex_2 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
style VE_cadherin fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| Adherens Junction Remodeling | mediates | process | 0.95 |
| Lymphatic Permeability | modulates | phenotype | 0.90 |
| Cytoskeletal Remodeling | modulates | process | 0.90 |
| Reelin Secretion | regulates | process | 0.90 |
| ARF6 | interacts_with | protein | 0.85 |
| Exocyst Complex | interacts_with | protein | 0.85 |
| VE-cadherin Trafficking | involved_in | process | 0.85 |
| ARF6 | participates_in | protein | 0.80 |
| exocyst complex | participates_in | entity | 0.80 |
| reelin | regulates | protein | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TMEM16F | regulates | gene | 1.00 |
| ARF6 | interacts_with | gene | 0.90 |
| Exocyst Complex | interacts_with | protein | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||